Anti-GFRA2 Antibody (CAB2954)
- SKU:
- CAB2954
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-GFRA2 Antibody |
| Antibody SKU: | CAB2954 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 360-464 of human GFRA2 (NP_001486.4). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, LO2, HepG2, HeLa, Mouse lung, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 360-464 of human GFRA2 (NP_001486.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DVNV SPKG PSFQ ATQA PRVE KTPS LPDD LSDS TSLG TSVI TTCT SVQE QGLK ANNS KELS MCFT ELTT NIIP GSNK VIKP NSGP SRAR PSAA LTVL SVLM LKLA L |
| Gene ID: | 2675 |
| Uniprot: | O00451 |
| Cellular Location: | Cell membrane, GPI-anchor, Lipid-anchor |
| Calculated MW: | 36kDa/39kDa/51kDa |
| Observed MW: | 34kDa/55kDa |
| Synonyms: | GFRA2, GDNFRB, NRTNR-ALPHA, NTNRA, RETL2, TRNR2 |
| Background: | Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | GFRA2: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Belongs to the GDNFR family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 8p21.3 Cellular Component: extrinsic to membrane; plasma membrane Molecular Function:glial cell line-derived neurotrophic factor receptor activity Biological Process: nervous system development; negative regulation of protein amino acid autophosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway |
| NCBI Summary: | Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] |
| UniProt Code: | O00451 |
| NCBI GenInfo Identifier: | 118582303 |
| NCBI Gene ID: | 2675 |
| NCBI Accession: | O00451.2 |
| UniProt Related Accession: | O00451 |
| Molecular Weight: | |
| NCBI Full Name: | GDNF family receptor alpha-2 |
| NCBI Synonym Full Names: | GDNF family receptor alpha 2 |
| NCBI Official Symbol: | GFRA2 |
| NCBI Official Synonym Symbols: | NTNRA; RETL2; TRNR2; GDNFRB; NRTNR-ALPHA |
| NCBI Protein Information: | GDNF family receptor alpha-2 |
| UniProt Protein Name: | GDNF family receptor alpha-2 |
| UniProt Synonym Protein Names: | GDNF receptor beta; GDNFR-beta; Neurturin receptor alpha; NRTNR-alpha; NTNR-alpha; RET ligand 2; TGF-beta-related neurotrophic factor receptor 2 |
| Protein Family: | GDNF family receptor |
| UniProt Gene Name: | GFRA2 |
| UniProt Entry Name: | GFRA2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GFRA2 antibody (CAB2954) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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