Anti-GEM Antibody (CAB7433)
- SKU:
- CAB7433
- Product type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-GEM Antibody |
| Antibody SKU: | CAB7433 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human GEM (NP_005252.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | HeLa, 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human GEM (NP_005252.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTLN NVTM RQGT VGMQ PQQQ RWSI PADG RHLM VQKE PHQY SHRN RHSA TPED HCRR SWSS DSTD SVIS SESG NTYY RVVL IGEQ GVGK STLA NIFA GVHD SMDS DCEV LGED TYER TLMV DGES ATII LLDM WENK GENE WLHD HCMQ VG |
| Gene ID: | 2669 |
| Uniprot: | P55040 |
| Cellular Location: | Cell membrane, Cytoplasmic side, Peripheral membrane protein |
| Calculated MW: | 33kDa |
| Observed MW: | 34kDa |
| Synonyms: | GEM, KIR |
| Background: | The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. |
| UniProt Protein Function: | GEM: Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Belongs to the small GTPase superfamily. RGK family. |
| UniProt Protein Details: | Protein type:G protein, monomeric; G protein; G protein, monomeric, RGK Chromosomal Location of Human Ortholog: 8q13-q21 Cellular Component: internal side of plasma membrane; midbody; spindle midzone; nucleus Molecular Function:calmodulin binding; GTPase activity; protein binding; GDP binding; GTP binding; magnesium ion binding Biological Process: mitosis; cell surface receptor linked signal transduction; metabolic process; small GTPase mediated signal transduction; metaphase plate congression; immune response; signal transduction; chromosome organization and biogenesis |
| NCBI Summary: | The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P55040 |
| NCBI GenInfo Identifier: | 1707896 |
| NCBI Gene ID: | 2669 |
| NCBI Accession: | P55040.1 |
| UniProt Secondary Accession: | P55040,B2RA31, |
| UniProt Related Accession: | P55040 |
| Molecular Weight: | 296 |
| NCBI Full Name: | GTP-binding protein GEM |
| NCBI Synonym Full Names: | GTP binding protein overexpressed in skeletal muscle |
| NCBI Official Symbol: | GEM |
| NCBI Official Synonym Symbols: | KIR |
| NCBI Protein Information: | GTP-binding protein GEM; RAS-like protein KIR; kinase-inducible Ras-like protein; GTP-binding mitogen-induced T-cell protein; GTP-binding protein overexpressed in skeletal muscle |
| UniProt Protein Name: | GTP-binding protein GEM |
| UniProt Synonym Protein Names: | GTP-binding mitogen-induced T-cell protein; RAS-like protein KIR |
| Protein Family: | Geminin |
| UniProt Gene Name: | GEM |
| UniProt Entry Name: | GEM_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GEM antibody (CAB7433) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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