Anti-GDA Antibody (CAB6441)

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SKU:
CAB6441
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-GDA Antibody
Antibody SKU:CAB6441
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 165-454 of human GDA (NP_004284.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:10 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, SKOV3, mouse liver, mouse brain, rat brain, Mouse lung, Rat testis, NCI-H460
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 165-454 of human GDA (NP_004284.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FVGK VCMD LNDT FPEY KETT EESI KETE RFVS EMLQ KNYS RVKP IVTP RFSL SCSE TLMG ELGN IAKT RDLH IQSH ISEN RDEV EAVK NLYP SYKN YTSV YDKN NLLT NKTV MAHG CYLS AEEL NVFH ERGA SIAH CPNS NLSL SSGF LNVL EVLK HEVK IGLG TDVA GGYS YSML DAIR RAVM VSNI LLIN KVNE KSLT LKEV FRLA TLGG SQAL GLDG EIGN FEVG KEFD AILI NPKA SDSP IDLF YGDF FGDI SEAV IQKF LYLG DDRN IEEV YVGG KQVV PFSS SV
Gene ID:9615
Uniprot:Q9Y2T3
Cellular Location:
Calculated MW:42kDa/51kDa/52kDa
Observed MW:51kDa
Synonyms:GDA, CYPIN, GUANASE, NEDASIN, GAH
Background:This gene encodes an enzyme responsible for the hydrolytic deamination of guanine. Studies in rat ortholog suggest this gene plays a role in microtubule assembly. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:GDA: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. Belongs to the ATZ/TRZ family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Nucleotide Metabolism - purine; EC 3.5.4.3; Hydrolase

Chromosomal Location of Human Ortholog: 9q21.13

Cellular Component: intracellular; cytosol

Molecular Function:guanine deaminase activity; zinc ion binding

Biological Process: nervous system development; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; purine nucleotide catabolic process; guanine catabolic process; purine base metabolic process

NCBI Summary:This gene encodes an enzyme responsible for the hydrolytic deamination of guanine. Studies in rat ortholog suggest this gene plays a role in microtubule assembly. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
UniProt Code:Q9Y2T3
NCBI GenInfo Identifier:9910736
NCBI Gene ID:9615
NCBI Accession:Q9Y2T3.1
UniProt Secondary Accession:Q9Y2T3,Q5SZC7, Q9H335, Q9ULG2, B4DTY5,
UniProt Related Accession:Q9Y2T3
Molecular Weight:454
NCBI Full Name:Guanine deaminase
NCBI Synonym Full Names:guanine deaminase
NCBI Official Symbol:GDA  
NCBI Official Synonym Symbols:CYPIN; GUANASE; NEDASIN  
NCBI Protein Information:guanine deaminase; GAH; p51-nedasin; guanine aminase; guanine aminohydrolase; cytoplasmic PSD95 interactor
UniProt Protein Name:Guanine deaminase
UniProt Synonym Protein Names:Guanine aminohydrolase; GAH; p51-nedasin
UniProt Gene Name:GDA  
UniProt Entry Name:GUAD_HUMAN
Anti-GDA Antibody (CAB6441)Western blot analysis of extracts of various cell lines, using GDA Antibody (CAB6441) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-GDA Antibody (CAB6441)Immunofluorescence analysis of A549 cells using GDA antibody (CAB6441). Blue: DAPI for nuclear staining.

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