Anti-GCLM Antibody (CAB11444)
- SKU:
- CAB11444
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-GCLM Antibody |
| Antibody SKU: | CAB11444 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human GCLM |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U2OS, HeLa, A-431 |
| Immunogen: | A synthesized peptide derived from human GCLM |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2730 |
| Uniprot: | P48507 |
| Cellular Location: | |
| Calculated MW: | 31kDa |
| Observed MW: | 30kd |
 | Western blot - GCLM Rabbit mAb (CAB11444) |
| Synonyms: | GLCLR |
| Background: | Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015] |
| UniProt Protein Function: | GCLM: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Other Amino Acids Metabolism - glutathione Chromosomal Location of Human Ortholog: 1p22.1 Cellular Component: cytosol; glutamate-cysteine ligase complex Molecular Function:enzyme regulator activity; glutamate-cysteine ligase activity; glutamate-cysteine ligase catalytic subunit binding Biological Process: glutamate metabolic process; glutathione biosynthetic process; positive regulation of glutamate-cysteine ligase activity; regulation of blood vessel size; response to drug; response to oxidative stress; sulfur amino acid metabolic process Disease: Myocardial Infarction, Susceptibility To |
| NCBI Summary: | Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015] |
| UniProt Code: | P48507 |
| NCBI GenInfo Identifier: | 1346188 |
| NCBI Gene ID: | 2730 |
| NCBI Accession: | P48507.1 |
| UniProt Secondary Accession: | P48507,Q6FHC1, Q9NPX9, Q9NU74, A8K334, D3DT45, M5A959 |
| UniProt Related Accession: | P48507 |
| Molecular Weight: | 28,135 Da |
| NCBI Full Name: | Glutamate--cysteine ligase regulatory subunit |
| NCBI Synonym Full Names: | glutamate-cysteine ligase modifier subunit |
| NCBI Official Symbol: | GCLM |
| NCBI Official Synonym Symbols: | GLCLR |
| NCBI Protein Information: | glutamate--cysteine ligase regulatory subunit |
| UniProt Protein Name: | Glutamate--cysteine ligase regulatory subunit |
| UniProt Synonym Protein Names: | GCS light chain; Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; Glutamate--cysteine ligase modifier subunit |
| Protein Family: | Glutamate--cysteine ligase regulatory |
| UniProt Gene Name: | GCLM |
| UniProt Entry Name: | GSH0_HUMAN |
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