Anti-GCG Antibody (CAB1119)
- SKU:
- CAB1119
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-GCG Antibody |
| Antibody SKU: | CAB1119 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-180 of human GCG (NP_002045.1). |
| Application: | IHC IF |
| Recommended Dilution: | IHC 1:100 - 1:200 IF 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-180 of human GCG (NP_002045.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RSLQ DTEE KSRS FSAS QADP LSDP DQMN EDKR HSQG TFTS DYSK YLDS RRAQ DFVQ WLMN TKRN RNNI AKRH DEFE RHAE GTFT SDVS SYLE GQAA KEFI AWLV KGRG RRDF PEEV AIVE ELGR RHAD GSFS DEMN TILD NLAA RDFI NWLI QTKI TDRK |
| Gene ID: | 2641 |
| Uniprot: | P01275 |
| Cellular Location: | Secreted |
| Calculated MW: | 20kDa |
| Observed MW: |
| Synonyms: | GCG, GLP-1, GLP1, GLP2, GRPP, glucagon |
| Background: | The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. |
| UniProt Protein Function: | GCG: Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. GLP-1 and GLP-2 are induced in response to nutrient ingestion. Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain. Belongs to the glucagon family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Hormone Chromosomal Location of Human Ortholog: 2q36-q37 Cellular Component: extracellular space; endoplasmic reticulum lumen; extracellular region; plasma membrane Molecular Function:identical protein binding; protein binding; hormone activity; glucagon receptor binding; receptor binding Biological Process: positive regulation of protein binding; positive regulation of histone H3-K4 methylation; signal transduction; positive regulation of peptidyl-serine phosphorylation; G-protein signaling, coupled to cAMP nucleotide second messenger; response to starvation; G-protein coupled receptor protein signaling pathway; cell proliferation; cellular protein metabolic process; positive regulation of protein kinase activity; positive regulation of cAMP biosynthetic process; energy reserve metabolic process; feeding behavior; regulation of insulin secretion; negative regulation of apoptosis |
| NCBI Summary: | The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P01275 |
| NCBI GenInfo Identifier: | 125987831 |
| NCBI Gene ID: | 2641 |
| NCBI Accession: | P01275.3 |
| UniProt Secondary Accession: | P01275,Q53TP6, A6NN65, |
| UniProt Related Accession: | P01275 |
| Molecular Weight: | 20,909 Da |
| NCBI Full Name: | Glucagon |
| NCBI Synonym Full Names: | glucagon |
| NCBI Official Symbol: | GCG |
| NCBI Official Synonym Symbols: | GLP1; GLP2; GRPP |
| NCBI Protein Information: | glucagon; preproglucagon; glucagon-like peptide 1; glucagon-like peptide 2; glicentin-related polypeptide |
| UniProt Protein Name: | Glucagon |
| UniProt Synonym Protein Names: | Incretin hormone |
| Protein Family: | Glucagon |
| UniProt Gene Name: | GCG |
| UniProt Entry Name: | GLUC_HUMAN |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using GCG antibody (CAB1119) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using GCG antibody (CAB1119) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of rat pancreas cells using GCG antibody (CAB1119) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of mouse pancreas cells using GCG antibody (CAB1119) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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