Anti-GATA6 Antibody (CAB16634)
- SKU:
- CAB16634
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-GATA6 Antibody |
| Antibody SKU: | CAB16634 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human GATA6 (NP_005248.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, Mouse lung |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human GATA6 (NP_005248.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KSKT CSGN SNNS IPMT PTST SSNS DDCS KNTS PTTQ PTAS GAGA PVMT GAGE STNP ENSE LKYS GQDG LYIG VSLA SPAE VTSS VRPD SWCA LALA |
| Gene ID: | 2627 |
| Uniprot: | Q92908 |
| Cellular Location: | Nucleus |
| Calculated MW: | 45kDa/60kDa |
| Observed MW: | 55kDa, 60kDa |
| Synonyms: | GATA6 |
| Background: | This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. |
| UniProt Protein Function: | GATA6: Transcriptional activator that regulates SEMA3C and PLXNA2. Thought to be important for regulating terminal differentiation and/or proliferation. Interacts with LMCD1. Expressed in heart, gut and gut-derived tissues. 2 isoforms of the human protein are produced by alternative initiation. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Transcription factor Chromosomal Location of Human Ortholog: 18q11.1-q11.2 Cellular Component: nucleoplasm; nucleus; transcription factor complex Molecular Function:chromatin binding; protein binding; protein kinase binding; transcription factor activity; transcription factor binding Biological Process: blood coagulation; cell development; cell fate commitment; cellular protein metabolic process; male gonad development; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor-beta1 production; negative regulation of transforming growth factor-beta2 production; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; response to drug; smooth muscle cell differentiation; transcription from RNA polymerase II promoter Disease: Atrial Septal Defect 9; Atrioventricular Septal Defect 5; Conotruncal Heart Malformations; Heart Defects, Congenital, And Other Congenital Anomalies; Tetralogy Of Fallot |
| NCBI Summary: | This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012] |
| UniProt Code: | Q92908 |
| NCBI GenInfo Identifier: | 215273987 |
| NCBI Gene ID: | 2627 |
| NCBI Accession: | Q92908.2 |
| UniProt Secondary Accession: | Q92908,P78327, B0YJ17, |
| UniProt Related Accession: | Q92908 |
| Molecular Weight: | 45,386 Da |
| NCBI Full Name: | Transcription factor GATA-6 |
| NCBI Synonym Full Names: | GATA binding protein 6 |
| NCBI Official Symbol: | GATA6 |
| NCBI Protein Information: | transcription factor GATA-6 |
| UniProt Protein Name: | Transcription factor GATA-6 |
| UniProt Synonym Protein Names: | GATA-binding factor 6 |
| Protein Family: | GATA transcription factor |
| UniProt Gene Name: | GATA6 |
| UniProt Entry Name: | GATA6_HUMAN |
 | Western blot analysis of extracts of 293T cells, using GATA6 antibody (CAB16634) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Western blot analysis of extracts of mouse lung, using GATA6 antibody (CAB16634) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min. |
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