| UniProt Protein Function: | GAS6: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ligand, receptor tyrosine kinase; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 13q34 Cellular Component: cytoplasm; endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi lumen Molecular Function:calcium ion binding; caspase inhibitor activity; molecular adaptor activity; phosphatidylserine binding; protein binding; protein tyrosine kinase activator activity; receptor agonist activity; receptor binding; receptor tyrosine kinase binding; voltage-gated calcium channel activity Biological Process: activation of protein kinase B; apoptotic cell clearance; blood coagulation; cell adhesion; cell cycle arrest; cell migration; cell proliferation; cell-substrate adhesion; cellular protein metabolic process; cellular response to starvation; entry of virus into host cell; enzyme linked receptor protein signaling pathway; ER to Golgi vesicle-mediated transport; leukocyte migration; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of interferon-gamma production; negative regulation of interleukin-1 secretion; negative regulation of interleukin-6 production; negative regulation of protein import into nucleus, translocation; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; negative regulation of tumor necrosis factor production; neuron migration; organ regeneration; peptidyl-glutamic acid carboxylation; peptidyl-serine phosphorylation; phagocytosis; platelet activation; platelet degranulation; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of fibroblast proliferation; positive regulation of glomerular filtration; positive regulation of natural killer cell differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of phagocytosis; positive regulation of protein amino acid phosphorylation; positive regulation of protein export from nucleus; positive regulation of protein kinase activity; positive regulation of protein kinase B signaling cascade; positive regulation of TOR signaling pathway; post-translational protein modification; protein amino acid phosphorylation; protein kinase B signaling cascade; regulation of growth; signal peptide processing; signal transduction; viral envelope fusion with host membrane; viral genome replication; virion attachment, binding of host cell surface receptor |
| NCBI Summary: | This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014] |
| UniProt Code: | Q14393 |
| NCBI GenInfo Identifier: | 48427995 |
| NCBI Gene ID: | 2621 |
| NCBI Accession: | Q14393.2 |
| UniProt Secondary Accession: | Q14393,Q6IMN1, Q7Z7N3, B3KRQ7, B3KVL4, E9PBL7, |
| UniProt Related Accession: | Q14393 |
| Molecular Weight: | 41,986 Da |
| NCBI Full Name: | Growth arrest-specific protein 6 |
| NCBI Synonym Full Names: | growth arrest specific 6 |
| NCBI Official Symbol: | GAS6 |
| NCBI Official Synonym Symbols: | AXSF; AXLLG |
| NCBI Protein Information: | growth arrest-specific protein 6 |
| UniProt Protein Name: | Growth arrest-specific protein 6 |
| UniProt Synonym Protein Names: | AXL receptor tyrosine kinase ligand |
| Protein Family: | Growth arrest-specific protein |
| UniProt Gene Name: | GAS6 |
| UniProt Entry Name: | GAS6_HUMAN |
