Anti-GAS2 Antibody (CAB1168)
- SKU:
- CAB1168
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-GAS2 Antibody |
| Antibody SKU: | CAB1168 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human GAS2 (NP_005247.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | SW620, Mouse liver, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human GAS2 (NP_005247.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MCTA LSPK VRSG PGLS DMHQ YSQW LASR HEAN LLPM KEDL ALWL TNLL GKEI TAET FMEK LDNG ALLC QLAE TMQE KFKE SMDA NKPT KNLP LKKI PCKT |
| Gene ID: | 2620 |
| Uniprot: | O43903 |
| Cellular Location: | Cytoplasm, Membrane, Peripheral membrane protein, cytoskeleton |
| Calculated MW: | 15kDa/34kDa |
| Observed MW: | 37kDa |
| Synonyms: | GAS2, GAS-2 |
| Background: | The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | GAS2: May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process. Belongs to the GAS2 family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Apoptosis Chromosomal Location of Human Ortholog: 11p14.3 Cellular Component: membrane; actin filament; cytosol Biological Process: regulation of cell shape; apoptosis; cell cycle arrest; cell structure disassembly during apoptosis |
| NCBI Summary: | The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009] |
| UniProt Code: | O43903 |
| NCBI GenInfo Identifier: | 3913719 |
| NCBI Gene ID: | 2620 |
| NCBI Accession: | O43903.1 |
| UniProt Secondary Accession: | O43903,Q6ICV8, Q7Z3X8, B2R9C8, D3DQZ0, |
| UniProt Related Accession: | O43903 |
| Molecular Weight: | 313 |
| NCBI Full Name: | Growth arrest-specific protein 2 |
| NCBI Synonym Full Names: | growth arrest-specific 2 |
| NCBI Official Symbol: | GAS2 |
| NCBI Protein Information: | growth arrest-specific protein 2; GAS-2 |
| UniProt Protein Name: | Growth arrest-specific protein 2 |
| Protein Family: | GAS2-like protein |
| UniProt Gene Name: | GAS2 |
| UniProt Entry Name: | GAS2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GAS2 antibody (CAB1168) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using GAS2 antibody (CAB1168) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of HeLa cells using GAS2 antibody (CAB1168). Blue: DAPI for nuclear staining. |
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