Anti-GALR2 Antibody (CAB17577)
- SKU:
- CAB17577
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| Antibody Name: | Anti-GALR2 Antibody |
| Antibody SKU: | CAB17577 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human GALR2 (NP_003848.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse brain, Mouse liver |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human GALR2 (NP_003848.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LLRG GQAV STTN LFIL NLGV ADLC FILC CVPF QATI YTLD GWVF GSLL CKAV HFLI FLTM HASS FTLA AVSL DRYL AIRY PLHS RELR TPRN ALAA IGLI W |
| Gene ID: | 8811 |
| Uniprot: | O43603 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 47kDa |
 | Western blot - GALR2 Polyclonal Antibody (CAB17577) |
| Synonyms: | GAL2-R, GALNR2, GALR-2, GALR2 |
| Background: | Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | GALR2: Receptor for the hormone galanin and for GALP. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)). Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 17q25.3 Cellular Component: cytosol; integral to membrane; integral to plasma membrane; plasma membrane Molecular Function:galanin receptor activity; neuropeptide binding; peptide hormone binding; protein binding Biological Process: cell surface receptor linked signal transduction; digestion; elevation of cytosolic calcium ion concentration; feeding behavior; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); inositol phosphate metabolic process; learning and/or memory; multicellular organismal development; muscle contraction; negative regulation of adenylate cyclase activity; neurite development; neuropeptide signaling pathway; phosphatidylinositol metabolic process; positive regulation of transcription from RNA polymerase II promoter; synaptic transmission |
| NCBI Summary: | Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43603 |
| NCBI GenInfo Identifier: | 6016094 |
| NCBI Gene ID: | 8811 |
| NCBI Accession: | O43603.1 |
| UniProt Secondary Accession: | O43603,Q32MN8, A5JUU4, |
| UniProt Related Accession: | O43603 |
| Molecular Weight: | 41,700 Da |
| NCBI Full Name: | Galanin receptor type 2 |
| NCBI Synonym Full Names: | galanin receptor 2 |
| NCBI Official Symbol: | GALR2 |
| NCBI Official Synonym Symbols: | GAL2-R; GALNR2; GALR-2 |
| NCBI Protein Information: | galanin receptor type 2 |
| UniProt Protein Name: | Galanin receptor type 2 |
| Protein Family: | Galanin receptor |
| UniProt Gene Name: | GALR2 |
| UniProt Entry Name: | GALR2_HUMAN |
Related Products
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
Human Anti-DSG3 antibody(anti-Desmoglein-3 antibody) ELISA Kit
Anti-WBP1 Antibody (CAB13212)
