Anti-GALK1 Antibody (CAB15274)
- SKU:
- CAB15274
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-GALK1 Antibody |
| Antibody SKU: | CAB15274 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human GALK1 (NP_000145.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | U-251MG, HepG2, HeLa, MCF7, Mouse heart, Mouse brain, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human GALK1 (NP_000145.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAL RQPQ VAEL LAEA RRAF REEF GAEP ELAV SAPG RVNL IGEH TDYN QGLV LPMA LELM TVLV GSPR KDGL VSLL TTSE GADE PQRL QFPL PTAQ RSLE PGTP RWAN YVKG VIQY YPAA |
| Gene ID: | 2584 |
| Uniprot: | P51570 |
| Cellular Location: | |
| Calculated MW: | 42kDa/45kDa |
| Observed MW: | 42kDa |
| Synonyms: | GALK1, GALK, GK1, HEL-S-19 |
| Background: | Galactokinase is a major enzyme for the metabolism of galactose and its deficiency causes congenital cataracts during infancy and presenile cataracts in the adult population. |
| UniProt Protein Function: | GALK1: Major enzyme for galactose metabolism. Defects in GALK1 are the cause of galactosemia II (GALCT2). Galactosemia II is an autosomal recessive deficiency characterized by congenital cataracts during infancy and presenile cataracts in the adult population. The cataracts are secondary to accumulation of galactitol in the lenses. Belongs to the GHMP kinase family. GalK subfamily. |
| UniProt Protein Details: | Protein type:Kinase, other; Carbohydrate Metabolism - galactose; EC 2.7.1.6; Carbohydrate Metabolism - amino sugar and nucleotide sugar Chromosomal Location of Human Ortholog: 17q24 Cellular Component: cytoplasm; cytosol; membrane Molecular Function:ATP binding; galactokinase activity; galactose binding Biological Process: galactose catabolic process; galactose metabolic process Disease: Galactokinase Deficiency |
| NCBI Summary: | Galactokinase is a major enzyme for the metabolism of galactose and its deficiency causes congenital cataracts during infancy and presenile cataracts in the adult population. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P51570 |
| NCBI GenInfo Identifier: | 1730187 |
| NCBI Gene ID: | 2584 |
| NCBI Accession: | P51570.1 |
| UniProt Secondary Accession: | P51570,B2RC07, B4E1G6, |
| UniProt Related Accession: | P51570 |
| Molecular Weight: | 45,358 Da |
| NCBI Full Name: | Galactokinase |
| NCBI Synonym Full Names: | galactokinase 1 |
| NCBI Official Symbol: | GALK1 |
| NCBI Official Synonym Symbols: | GK1; GALK; HEL-S-19 |
| NCBI Protein Information: | galactokinase |
| UniProt Protein Name: | Galactokinase |
| UniProt Synonym Protein Names: | Galactose kinase |
| UniProt Gene Name: | GALK1 |
| UniProt Entry Name: | GALK1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GALK1 antibody (CAB15274) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60S. |
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