Anti-GABRB1 Antibody (CAB16015)
- SKU:
- CAB16015
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| Antibody Name: | Anti-GABRB1 Antibody |
| Antibody SKU: | CAB16015 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human GABRB1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-251MG, mouse brain, rat brain |
| Immunogen: | A synthetic peptide of human GABRB1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2560 |
| Uniprot: | P18505 |
| Cellular Location: | |
| Calculated MW: | 10kDa/54kDa |
| Observed MW: | 54kDa |
| Synonyms: | GABRB1, EIEE45 |
| Background: | The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. |
| UniProt Protein Function: | GABRB1: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB1 sub-subfamily. |
| UniProt Protein Details: | Protein type:Channel, chloride; Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, ion channel; Channel, ligand-gated Chromosomal Location of Human Ortholog: 4p12 Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction Molecular Function:chloride channel activity; GABA-A receptor activity; ligand-gated ion channel activity; extracellular ligand-gated ion channel activity Biological Process: synaptic transmission; transport; ion transport; signal transduction; transmembrane transport |
| NCBI Summary: | The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P18505 |
| NCBI GenInfo Identifier: | 194097327 |
| NCBI Gene ID: | 2560 |
| NCBI Accession: | NP_000803.2 |
| UniProt Related Accession: | P18505 |
| Molecular Weight: | ~ 54kDa |
| NCBI Full Name: | gamma-aminobutyric acid receptor subunit beta-1 |
| NCBI Synonym Full Names: | gamma-aminobutyric acid type A receptor subunit beta1 |
| NCBI Official Symbol: | GABRB1 |
| NCBI Official Synonym Symbols: | EIEE45 |
| NCBI Protein Information: | gamma-aminobutyric acid receptor subunit beta-1 |
| UniProt Protein Name: | Gamma-aminobutyric acid receptor subunit beta-1 |
| UniProt Synonym Protein Names: | GABA(A) receptor subunit beta-1 |
| UniProt Gene Name: | GABRB1 |
| UniProt Entry Name: | GBRB1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GABRB1 antibody (CAB16015) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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Anti-GABA A Receptor beta 1 (GABRB1) Antibody (CAB19681)
