| Synonyms: | FZD4, CD344, EVR1, FEVR, FZD4S, Fz-4, Fz4, FzE4, GPCR, hFz4 |
| UniProt Protein Function: | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
| NCBI Summary: | This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9ULV1 |
| NCBI GenInfo Identifier: | 62298045 |
| NCBI Gene ID: | 8322 |
| NCBI Accession: | Q9ULV1.2 |
| UniProt Secondary Accession: | Q9ULV1,Q14C97, Q6S9E4, A8K9Q3, |
| UniProt Related Accession: | Q9ULV1 |
| Molecular Weight: | 59,881 Da |
| NCBI Full Name: | Frizzled-4 |
| NCBI Synonym Full Names: | frizzled class receptor 4 |
| NCBI Official Symbol: | FZD4 |
| NCBI Official Synonym Symbols: | Fz4; EVR1; FEVR; Fz-4; FzE4; GPCR; hFz4; CD344; FZD4S |
| NCBI Protein Information: | frizzled-4 |
| UniProt Protein Name: | Frizzled-4 |
| UniProt Synonym Protein Names: | FzE4; CD_antigen: CD344 |
| UniProt Gene Name: | FZD4 |
