Anti-FUT8 Antibody (CAB12933)
- SKU:
- CAB12933
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-FUT8 Antibody |
| Antibody SKU: | CAB12933 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 376-575 of human FUT8 (NP_835367.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 376-575 of human FUT8 (NP_835367.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FHPI EEYM VHVE EHFQ LLAR RMQV DKKR VYLA TDDP SLLK EAKT KYPN YEFI SDNS ISWS AGLH NRYT ENSL RGVI LDIH FLSQ ADFL VCTF SSQV CRVA YEIM QTLH PDAS ANFH SLDD IYYF GGQN AHNQ IAIY AHQP RTAD EIPM EPGD IIGV AGNH WDGY SKGV NRKL GRTG LYPS YKVR EKIE TVKY PTYP EAEK |
| Gene ID: | 2530 |
| Uniprot: | Q9BYC5 |
| Cellular Location: | Golgi apparatus, Golgi stack membrane, Single-pass type II membrane protein |
| Calculated MW: | 19kDa/35kDa/47kDa/66kDa |
| Observed MW: | 75kDa |
| Synonyms: | FUT8 |
| Background: | This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | FUT8: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.4.1.68; Glycan Metabolism - N-glycan biosynthesis; Glycan Metabolism - keratan sulfate biosynthesis; Membrane protein, integral; Motility/polarity/chemotaxis; Transferase Chromosomal Location of Human Ortholog: 14q23.3 Cellular Component: cytosol; Golgi membrane; membrane Molecular Function:glycoprotein 6-alpha-L-fucosyltransferase activity Biological Process: GDP-L-fucose metabolic process; N-glycan processing; oligosaccharide biosynthetic process; protein amino acid N-linked glycosylation; protein amino acid N-linked glycosylation via asparagine |
| NCBI Summary: | This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011] |
| UniProt Code: | Q9BYC5 |
| NCBI GenInfo Identifier: | 20138326 |
| NCBI Gene ID: | 2530 |
| NCBI Accession: | Q9BYC5.2 |
| UniProt Secondary Accession: | Q9BYC5,O00235, Q8IUA5, Q9BYC6, Q9P2U5, Q9P2U6, B4DFS7 G3V5N0, |
| UniProt Related Accession: | Q9BYC5 |
| Molecular Weight: | Calculated MW: 19kDa/35kDa/47kDa/66kDaObserved MW: 75kDa |
| NCBI Full Name: | Alpha-(1,6)-fucosyltransferase |
| NCBI Synonym Full Names: | fucosyltransferase 8 |
| NCBI Official Symbol: | FUT8 |
| NCBI Protein Information: | alpha-(1,6)-fucosyltransferase |
| UniProt Protein Name: | Alpha-(1,6)-fucosyltransferase |
| UniProt Synonym Protein Names: | Fucosyltransferase 8; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase; GDP-fucose--glycoprotein fucosyltransferase; Glycoprotein 6-alpha-L-fucosyltransferase |
| Protein Family: | Probable fucosyltransferase |
| UniProt Gene Name: | FUT8 |
 | Western blot analysis of extracts of various cell lines, using FUT8 antibody (CAB12933) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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