Anti-FUT1 Antibody (CAB15585)
- SKU:
- CAB15585
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-FUT1 Antibody |
| Antibody SKU: | CAB15585 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 130-310 of human FUT1 (NP_000139.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 130-310 of human FUT1 (NP_000139.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VLAP EVDS RTPW RELQ LHDW MSEE YADL RDPF LKLS GFPC SWTF FHHL REQI RREF TLHD HLRE EAQS VLGQ LRLG RTGD RPRT FVGV HVRR GDYL QVMP QRWK GVVG DSAY LRQA MDWF RARH EAPV FVVT SNGM EWCK ENID TSQG DVTF AGDG QEAT PWKD FALL TQCN HTIM TIGT F |
| Gene ID: | 2523 |
| Uniprot: | P19526 |
| Cellular Location: | Golgi apparatus, Golgi stack membrane, Single-pass type II membrane protein |
| Calculated MW: | 41kDa |
| Observed MW: | 55kDa |
| Synonyms: | FUT1, H, HH, HSC |
| Background: | This gene encodes a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the synthesis of soluble A and B antigens. This is one of two genes encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group. |
| UniProt Protein Function: | FUT1: Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values. Belongs to the glycosyltransferase 11 family. |
| UniProt Protein Details: | Protein type:Transferase; Glycan Metabolism - glycosphingolipid biosynthesis - globo series; Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; EC 2.4.1.69; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: Golgi apparatus; integral to plasma membrane; membrane Molecular Function:fucosyltransferase activity; galactoside 2-alpha-L-fucosyltransferase activity Biological Process: carbohydrate metabolic process; protein amino acid glycosylation |
| NCBI Summary: | The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P19526 |
| NCBI GenInfo Identifier: | 120636 |
| NCBI Gene ID: | 2523 |
| NCBI Accession: | P19526.1 |
| UniProt Secondary Accession: | P19526,O14505, O14506, O14507, |
| UniProt Related Accession: | P19526 |
| Molecular Weight: | 41,251 Da |
| NCBI Full Name: | Galactoside 2-alpha-L-fucosyltransferase 1 |
| NCBI Synonym Full Names: | fucosyltransferase 1 (H blood group) |
| NCBI Official Symbol: | FUT1 |
| NCBI Official Synonym Symbols: | H; HH; HSC |
| NCBI Protein Information: | galactoside 2-alpha-L-fucosyltransferase 1 |
| UniProt Protein Name: | Galactoside 2-alpha-L-fucosyltransferase 1 |
| UniProt Synonym Protein Names: | Alpha(1,2)FT 1; Blood group H alpha 2-fucosyltransferase; Fucosyltransferase 1; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1 |
| Protein Family: | Galactoside 2-alpha-L-fucosyltransferase |
| UniProt Gene Name: | FUT1 |
| UniProt Entry Name: | FUT1_HUMAN |
 | Western blot analysis of extracts of rat brain, using FUT1 antibody (CAB15585) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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