Anti-FSHB Antibody (CAB14532)
- SKU:
- CAB14532
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-FSHB Antibody |
| Antibody SKU: | CAB14532 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-129 of human FSHB (NP_000501.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Mouse lung, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-129 of human FSHB (NP_000501.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NSCE LTNI TIAI EKEE CRFC ISIN TTWC AGYC YTRD LVYK DPAR PKIQ KTCT FKEL VYET VRVP GCAH HADS LYTY PVAT QCHC GKCD SDST DCTV RGLG PSYC SFGE MKE |
| Gene ID: | 2488 |
| Uniprot: | P01225 |
| Cellular Location: | Secreted |
| Calculated MW: | 14kDa |
| Observed MW: | 14kDa |
| Synonyms: | FSHB, HH24 |
| Background: | The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. |
| UniProt Protein Function: | FSHB: Stimulates development of follicle and spermatogenesis in the reproductive organs. Defects in FSHB are a cause of isolated follicle- stimulating hormone deficiency (IFSHD). Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men. Belongs to the glycoprotein hormones subunit beta family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 11p13 Cellular Component: cytoplasm; extracellular region Molecular Function:follicle-stimulating hormone activity; hormone activity; protein binding Biological Process: female gamete generation; female pregnancy; peptide hormone processing; progesterone biosynthetic process; signal transduction; transforming growth factor beta receptor signaling pathway Disease: Follicle-stimulating Hormone Deficiency, Isolated |
| NCBI Summary: | The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P01225 |
| NCBI GenInfo Identifier: | 120552 |
| NCBI Gene ID: | 2488 |
| NCBI Accession: | P01225.2 |
| UniProt Secondary Accession: | P01225,Q14D61, A2TF08, A5JVV3, |
| UniProt Related Accession: | P01225 |
| Molecular Weight: | 14,700 Da |
| NCBI Full Name: | Follitropin subunit beta |
| NCBI Synonym Full Names: | follicle stimulating hormone beta subunit |
| NCBI Official Symbol: | FSHB |
| NCBI Official Synonym Symbols: | HH24 |
| NCBI Protein Information: | follitropin subunit beta |
| UniProt Protein Name: | Follitropin subunit beta |
| UniProt Synonym Protein Names: | Follicle-stimulating hormone beta subunit; FSH-B; FSH-beta; Follitropin beta chain |
| Protein Family: | Follitropin |
| UniProt Gene Name: | FSHB |
| UniProt Entry Name: | FSHB_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FSHB antibody (CAB14532) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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