Anti-FSCN1 Antibody (CAB13355)
- SKU:
- CAB13355
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-FSCN1 Antibody |
| Antibody SKU: | CAB13355 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 260-380 of human FSCN1 (NP_003079.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, HeLa, U-251MG, Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 260-380 of human FSCN1 (NP_003079.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | CAQV VLQA ANER NVST RQGM DLSA NQDE ETDQ ETFQ LEID RDTK KCAF RTHT GKYW TLTA TGGV QSTA SSKN ASCY FDIE WRDR RITL RASN GKFV TSKK NGQL AASV ETAG DSEL FLMK L |
| Gene ID: | 6624 |
| Uniprot: | Q16658 |
| Cellular Location: | Cell junction, Cell projection, Cytoplasm, cytoskeleton, cytosol, filopodium, invadopodium, microvillus |
| Calculated MW: | 54kDa |
| Observed MW: | 55kDa |
| Synonyms: | FSCN1, FAN1, HSN, SNL, p55, fascin |
| Background: | This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. |
| UniProt Protein Function: | Fascin: Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Associates with beta-catenin. Ubiquitous. Belongs to the fascin family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytoskeletal; Actin-binding Chromosomal Location of Human Ortholog: 7p22 Cellular Component: cytoplasm; stress fiber; cell junction; cytosol; actin cytoskeleton; filopodium Molecular Function:protein binding, bridging; actin filament binding; protein binding; drug binding; actin binding Biological Process: cell proliferation; actin filament bundle formation; cell migration; cell motility involved in cell locomotion; actin cytoskeleton organization and biogenesis |
| NCBI Summary: | This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q16658 |
| NCBI GenInfo Identifier: | 2498357 |
| NCBI Gene ID: | 6624 |
| NCBI Accession: | Q16658.3 |
| UniProt Related Accession: | Q16658 |
| Molecular Weight: | 54kDa |
| NCBI Full Name: | Fascin |
| NCBI Synonym Full Names: | fascin actin-bundling protein 1 |
| NCBI Official Symbol: | FSCN1 |
| NCBI Official Synonym Symbols: | HSN; SNL; p55; FAN1 |
| NCBI Protein Information: | fascin |
| UniProt Protein Name: | Fascin |
| UniProt Synonym Protein Names: | 55 kDa actin-bundling protein; Singed-like protein; p55 |
| Protein Family: | Fascin |
| UniProt Gene Name: | FSCN1 |
| UniProt Entry Name: | FSCN1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FSCN1 antibody (CAB13355) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using FSCN1 antibody (CAB13355) at dilution of 1:100 (40x lens). |
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