Anti-FLRT2 항체 (CAB17668)

Antibody Name:	Anti-FLRT2 Antibody
Antibody SKU:	CAB17668
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse
Host Species:	Rabbit
Immunogen:	A synthetic peptide of Human FLRT2.

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse
Positive Samples:	Mouse brain

Immunogen:	A synthetic peptide of Human FLRT2.
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	23768
Uniprot:	O43155
Cellular Location:
Calculated MW:
Observed MW:	80kDa

Western blot - FLRT2 Polyclonal Antibody (CAB17668)

Synonyms:

FLRT2

Background:

This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

UniProt Protein Function:	Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis.
NCBI Summary:	This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
UniProt Code:	O43155
NCBI GenInfo Identifier:	1071034772
NCBI Gene ID:	23768
NCBI Accession:	NP_001333072.1
UniProt Secondary Accession:	O43155,A0AV84, B7ZLP3,
UniProt Related Accession:	O43155
Molecular Weight:	Molecular Mass: 57.3kDaActual Protein Molecular Mass: 78kDa
NCBI Full Name:	leucine-rich repeat transmembrane protein FLRT2
NCBI Synonym Full Names:	fibronectin leucine rich transmembrane protein 2
NCBI Official Symbol:	FLRT2
NCBI Protein Information:	leucine-rich repeat transmembrane protein FLRT2
UniProt Protein Name:	Leucine-rich repeat transmembrane protein FLRT2
UniProt Synonym Protein Names:	Fibronectin-like domain-containing leucine-rich transmembrane protein 2
Protein Family:	Leucine-rich repeat transmembrane protein
UniProt Gene Name:	FLRT2

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)