Anti-FLG Antibody (CAB20011)
- SKU:
- CAB20011
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| Antibody Name: | Anti-FLG Antibody |
| Antibody SKU: | CAB20011 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human FLG. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A375, A431, HepG2, TE-1, SGC7901, mouse stomach, mouse liver, rat liver |
| Immunogen: | Recombinant protein of human FLG. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2312 |
| Uniprot: | P20930 |
| Cellular Location: | |
| Calculated MW: | 38-75kDa |
| Observed MW: | 30-100kDa |
 | Western blot - FLG Rabbit pAb (CAB20011) |
| Synonyms: | ATOD2 |
| Background: | The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris. |
| UniProt Protein Function: | FLG: Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. Defects in FLG are the cause of ichthyosis vulgaris (VI); also known as ichthyosis simplex. Ichthyosis vulgaris is the most common form of ichthyosis inherited as an autosomal dominant trait. It is characterized by palmar hyperlinearity, keratosis pilaris and a fine scale that is most prominent over the lower abdomen, arms, and legs. Ichthyosis vulgaris is characterized histologically by absent or reduced keratohyalin granules in the epidermis and mild hyperkeratosis. The disease can be associated with frequent asthma, eczema or hay fever. Defects in FLG are a cause of susceptibility to dermatitis atopic type 2 (ATOD2). Atopic dermatitis is a complex, inflammatory disease with multiple alleles at several loci thought to be involved in the pathogenesis. It commonly begins in infancy or early childhood and is characterized by a chronic relapsing form of skin inflammation, a disturbance of epidermal barrier function that culminates in dry skin, and IgE- mediated sensitization to food and environmental allergens. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. Belongs to the S100-fused protein family. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: intermediate filament; intracellular membrane-bound organelle; nucleus Molecular Function:calcium ion binding; protein binding; structural molecule activity Biological Process: keratinocyte differentiation; multicellular organismal development Disease: Dermatitis, Atopic, 2; Ichthyosis Vulgaris |
| NCBI Summary: | The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009] |
| UniProt Code: | P20930 |
| NCBI GenInfo Identifier: | 84028206 |
| NCBI Gene ID: | 2312 |
| NCBI Accession: | P20930.3 |
| UniProt Secondary Accession: | P20930,Q01720, Q5T583, Q9UC71, |
| UniProt Related Accession: | P20930 |
| Molecular Weight: | |
| NCBI Full Name: | Filaggrin |
| NCBI Synonym Full Names: | filaggrin |
| NCBI Official Symbol: | FLG |
| NCBI Official Synonym Symbols: | ATOD2 |
| NCBI Protein Information: | filaggrin |
| UniProt Protein Name: | Filaggrin |
| Protein Family: | Filaggrin |
| UniProt Gene Name: | FLG |
| UniProt Entry Name: | FILA_HUMAN |
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