Anti-FKBP1B Antibody (CAB16375)
- SKU:
- CAB16375
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-FKBP1B Antibody |
| Antibody SKU: | CAB16375 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-80 of human FKBP1B (NP_473374.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 22Rv1, Mouse brain, Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-80 of human FKBP1B (NP_473374.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGVE IETI SPGD GRTF PKKG QTCV VHYT GMLQ NGKK FDSS RDRN KPFK FRIG KQEV IKGF EEGA AQLG PLSP LPIC PHPC |
| Gene ID: | 2281 |
| Uniprot: | P68106 |
| Cellular Location: | Cytoplasm, Sarcoplasmic reticulum |
| Calculated MW: | 8kDa/11kDa |
| Observed MW: | 13kDa |
| Synonyms: | FKBP1B, FKBP12.6, FKBP1L, OTK4, PKBP1L, PPIase |
| Background: | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. |
| UniProt Protein Function: | FKBP1B: Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the FKBP-type PPIase family. FKBP1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Isomerase; EC 5.2.1.8 Chromosomal Location of Human Ortholog: 2p23.3 Cellular Component: cytoplasm; cytosol; membrane; sarcoplasmic reticulum membrane; Z disc Molecular Function:calcium channel inhibitor activity; FK506 binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; receptor binding; ryanodine-sensitive calcium-release channel activity Biological Process: 'de novo' protein folding; cytosolic calcium ion homeostasis; negative regulation of heart rate; negative regulation of protein phosphatase type 2B activity; negative regulation of release of sequestered calcium ion into cytosol; positive regulation of sequestering of calcium ion; protein maturation via protein folding; protein peptidyl-prolyl isomerization; protein refolding; response to redox state |
| NCBI Summary: | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P68106 |
| NCBI GenInfo Identifier: | 61224185 |
| NCBI Gene ID: | 2281 |
| NCBI Accession: | P68106.2 |
| UniProt Secondary Accession: | P68106,Q13664, Q16645, Q53TM2, Q9BQ40, |
| UniProt Related Accession: | P68106 |
| Molecular Weight: | 8,802 Da |
| NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase FKBP1B |
| NCBI Synonym Full Names: | FK506 binding protein 1B |
| NCBI Official Symbol: | FKBP1B |
| NCBI Official Synonym Symbols: | OTK4; FKBP1L; PKBP1L; PPIase; FKBP12.6 |
| NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase FKBP1B |
| UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase FKBP1B |
| UniProt Synonym Protein Names: | 12.6 kDa FK506-binding protein; 12.6 kDa FKBP; FKBP-12.6; FK506-binding protein 1B; FKBP-1B; Immunophilin FKBP12.6; Rotamase; h-FKBP-12 |
| Protein Family: | Peptidyl-prolyl cis-trans isomerase |
| UniProt Gene Name: | FKBP1B |
| UniProt Entry Name: | FKB1B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FKBP1B antibody (CAB16375) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded rat heart using FKBP1B antibody (CAB16375) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse spinal cord using FKBP1B antibody (CAB16375) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse heart using FKBP1B antibody (CAB16375) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of L929 cells using FKBP1B Polyclonal Antibody (CAB16375) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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