Anti-FHL3 Antibody (CAB8679)
- SKU:
- CAB8679
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-FHL3 Antibody |
| Antibody SKU: | CAB8679 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human FHL3 (NP_004459.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | LO2, HT-1080, HL-60, Mouse skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human FHL3 (NP_004459.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSES FDCA KCNE SLYG RKYI QTDS GPYC VPCY DNTF ANTC AECQ QLIG HDSR ELFY EDRH FHEG CFRC CRCQ RSLA DEPF TCQD SELL CNDC YCSA FSSQ CSAC GETV MPGS RKLE YGGQ TWHE HCFL CSGC EQPL GSRS FVPD KGAH YCVP CYEN KFAP RCAR CSKT LTQG GVTY RDQP WHRE CLVC TGCQ TPLA GQQF TSRD EDPY CVAC FGEL FAPK CSSC KRPI VGLG GGKY VSFE DRHW HHNC FSCA RCST SLVG QGFV PDGD QVLC QGCS QAGP |
| Gene ID: | 2275 |
| Uniprot: | Q13643 |
| Cellular Location: | |
| Calculated MW: | 31kDa |
| Observed MW: | 31-36kDa |
| Synonyms: | FHL3, SLIM2 |
| Background: | The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene. |
| NCBI Summary: | The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q13643 |
| NCBI GenInfo Identifier: | 54112385 |
| NCBI Gene ID: | 2275 |
| NCBI Accession: | NP_004459.2 |
| UniProt Secondary Accession: | Q13643,Q6I9T0, Q9BVA2, D3DPT6, |
| UniProt Related Accession: | Q13643 |
| Molecular Weight: | 31,192 Da |
| NCBI Full Name: | four and a half LIM domains protein 3 isoform 1 |
| NCBI Synonym Full Names: | four and a half LIM domains 3 |
| NCBI Official Symbol: | FHL3 |
| NCBI Official Synonym Symbols: | SLIM2 |
| NCBI Protein Information: | four and a half LIM domains protein 3 |
| UniProt Protein Name: | |
| Protein Family: | Four and a half LIM domains protein |
| UniProt Gene Name: |
 | Western blot analysis of extracts of various cell lines, using FHL3 antibody (CAB8679) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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