Anti-FGA Antibody (CAB1453)

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SKU:
CAB1453
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
Frequently bought together:

Description

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Antibody Name:Anti-FGA Antibody
Antibody SKU:CAB1453
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FGA (NP_068657.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, Mouse liver, Rat liver
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FGA (NP_068657.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VERH QSAC KDSD WPFC SDED WNYK CPSG CRMK GLID EVNQ DFTN RINK LKNS LFEY QKNN KDSH SLTT NIME ILRG DFSS ANNR DNTY NRVS EDLR SRIE VLKR KVIE KVQH IQLL QKNV RAQL VDMK RLEV DIDI KIRS CRGS CSRA LARE VDLK DYED QQKQ LEQV IAKD LLPS RDRQ HLPL IKMK PVPD LVPG NFKS QLQK VPPE WKAL TDMP QMRM ELER PGGN EITR GGST SYGT GSET ESPR NPSS AGSW NSGS SGPG STGN RNPG SSGT GGTA TWKP GSSG PGST GSWN SGSS
Gene ID:2243
Uniprot:P02671
Cellular Location:Secreted
Calculated MW:69kDa/94kDa
Observed MW:95KDa/60-70KDa
Synonyms:FGA, Fib2
Background:This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing.
UniProt Protein Function:FGA: Fibrinogen has a double Function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Defects in FGA are a cause of congenital afibrinogenemia (CAFBN). This is a rare autosomal recessive disorder characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. The majority of cases of afibrinogenemia are due to truncating mutations. Variations in position Arg-35 (the site of cleavage of fibrinopeptide a by thrombin) leads to alpha- dysfibrinogenemias. Defects in FGA are a cause of amyloidosis type 8 (AMYL8); also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q28

Cellular Component: extracellular space; cell surface; fibrinogen complex; plasma membrane; extracellular region; cell cortex; vesicle; external side of plasma membrane

Molecular Function:protein binding, bridging; protein binding; cell adhesion molecule binding; structural molecule activity; receptor binding

Biological Process: protein polymerization; platelet activation; extracellular matrix organization and biogenesis; positive regulation of heterotypic cell-cell adhesion; cell-matrix adhesion; signal transduction; cellular protein complex assembly; platelet degranulation; positive regulation of protein secretion; positive regulation of vasoconstriction; innate immune response; blood coagulation; response to calcium ion; positive regulation of exocytosis

Disease: Amyloidosis, Familial Visceral; Afibrinogenemia, Congenital; Dysfibrinogenemia, Congenital

NCBI Summary:The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. [provided by RefSeq, Jul 2008]
UniProt Code:P02671
NCBI GenInfo Identifier:1706799
NCBI Gene ID:2243
NCBI Accession:P02671.2
UniProt Secondary Accession:P02671,Q4QQH7, Q9BX62, Q9UCH2, A8K3E4, D3DP14, D3DP15
UniProt Related Accession:P02671
Molecular Weight:69,757 Da
NCBI Full Name:Fibrinogen alpha chain
NCBI Synonym Full Names:fibrinogen alpha chain
NCBI Official Symbol:FGA  
NCBI Official Synonym Symbols:Fib2  
NCBI Protein Information:fibrinogen alpha chain; fibrinogen, A alpha polypeptide
UniProt Protein Name:Fibrinogen alpha chain
Protein Family:Fibrinogen
UniProt Gene Name:FGA  
UniProt Entry Name:FIBA_HUMAN
Anti-FGA Antibody (CAB1453)Western blot analysis of extracts of various cell lines, using FGA antibody (CAB1453) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Anti-FGA Antibody (CAB1453)Immunohistochemistry of paraffin-embedded human placenta using FGA Rabbit pAb (CAB1453) at dilution of 1:100 (40x lens).

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