Anti-FDXR Antibody (CAB3860)
- SKU:
- CAB3860
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-FDXR Antibody |
| Antibody SKU: | CAB3860 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 252-491 of human FDXR (NP_077728.3). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, NCI-H460, Mouse kidney, Mouse testis, Mouse ovary, Rat lung, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 252-491 of human FDXR (NP_077728.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PILD PVDF LGLQ DKIK EVPR PRKR LTEL LLRT ATEK PGPA EAAR QASA SRAW GLRF FRSP QQVL PSPD GRRA AGVR LAVT RLEG VDEA TRAV PTGD MEDL PCGL VLSS IGYK SRPV DPSV PFDS KLGV IPNV EGRV MDVP GLYC SGWV KRGP TGVI ATTM TDSF LTGQ MLLQ DLKA GLLP SGPR PGYA AIQA LLSS RGVR PVSF SDWE KLDA EEVA RGQG TGKP REKL VDPQ EMLR LLGH |
| Gene ID: | 2232 |
| Uniprot: | P22570 |
| Cellular Location: | Mitochondrion matrix |
| Calculated MW: | 48kDa/49kDa/52kDa/53kDa/54kDa/57kDa/58kDa |
| Observed MW: | 45kDa |
| Synonyms: | FDXR, ADXR |
| Background: | This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants have been found for this gene. |
| UniProt Protein Function: | FDXR: Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. Belongs to the ferredoxin--NADP reductase type 1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oxidoreductase; Mitochondrial; EC 1.18.1.6 Chromosomal Location of Human Ortholog: 17q25.1 Cellular Component: mitochondrion; mitochondrial matrix Molecular Function:protein binding; ferredoxin-NADP+ reductase activity; NADPH-adrenodoxin reductase activity Biological Process: steroid metabolic process; cholesterol metabolic process; ubiquinone biosynthetic process; generation of precursor metabolites and energy; xenobiotic metabolic process; C21-steroid hormone biosynthetic process; steroid biosynthetic process; sterol metabolic process |
| NCBI Summary: | This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012] |
| UniProt Code: | P22570 |
| NCBI GenInfo Identifier: | 85681283 |
| NCBI Gene ID: | 2232 |
| NCBI Accession: | P22570.3 |
| UniProt Related Accession: | P22570 |
| Molecular Weight: | Observed Molecular Weight: (Observed)53kD.Predicted Molecular Weight: (Calculated)54kDa. |
| NCBI Full Name: | NADPH:adrenodoxin oxidoreductase, mitochondrial |
| NCBI Synonym Full Names: | ferredoxin reductase |
| NCBI Official Symbol: | FDXR |
| NCBI Official Synonym Symbols: | ADR; ADXR; ANOA |
| NCBI Protein Information: | NADPH:adrenodoxin oxidoreductase, mitochondrial |
| UniProt Protein Name: | NADPH:adrenodoxin oxidoreductase, mitochondrial |
| UniProt Synonym Protein Names: | Ferredoxin--NADP(+) reductase; Ferredoxin reductase |
| UniProt Gene Name: | FDXR |
| UniProt Entry Name: | ADRO_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FDXR antibody (CAB3860) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using FDXR antibody (CAB3860) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human esophagus using FDXR antibody (CAB3860) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using FDXR antibody (CAB3860) at dilution of 1:100 (40x lens). |
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