Anti-FCGR1A Antibody,PE Conjugated (MACO0312)
- SKU:
- MACO0312
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1
- Application:
- ELISA
- Application:
- IF
- Application:
- FC
- Antibody type:
- Monoclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Product Name: | Anti-FCGR1A Antibody,PE Conjugated |
| Product Sku: | MACO0312 |
| Size: | 100ul |
| Host Species: | Mouse |
| Tested Applications: | ELISA, IF, FC |
| Recommended Dilutions: | IF:1:100-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Protein |
| Form: | Liquid |
| Storage Buffer: | Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide and 0.2% (w/v) BSA |
| Purification Method: | Affinity purified |
| Clonality: | Monoclonal |
| Isotype: | IgG1 |
| Conjugate: | Non-conjugated |
| Background: | CT101 reacts with high affinity receptor for IgG (FcyRI), a 75 kDa type 1 trasmembrane glycoprotein. CD64 is expressed on monocytes and macrophages but not on lymphocytes or resting granulocytes. CD64 play a role in phagocytosis, and antibody dependent cellular cytotoxicity ( ADCC). It also participates in cytokine and superoxide release.1. Ledbetter, J et al. (1981) J Exp Med 153:310-323.2. Haynes, B et al. (1986) Leukocyte Typing II: Human T lymphocytes. New York: Sprimger-Verlag; 3-30.3. Clevers H et al. (1988). Ann Rev Immunol 6: 629-662.4. Barclay, N et al. (1993). The Leucocyte Factsbook. Academic Press. San Diego. |
| Synonyms: |
| UniProt Protein Function: | FCGR1A: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Belongs to the immunoglobulin superfamily. FCGR1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q21.2-q21.3 Cellular Component: early endosome membrane; plasma membrane; integral to membrane Molecular Function:protein binding; IgG binding; receptor signaling protein activity Biological Process: antigen processing and presentation of peptide antigen via MHC class I; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I; immune response; signal transduction; phagocytosis, engulfment |
| NCBI Summary: | This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P12314 |
| NCBI GenInfo Identifier: | 50403717 |
| NCBI Gene ID: | 2209 |
| NCBI Accession: | P12314.2 |
| UniProt Related Accession: | P12314 |
| Molecular Weight: | |
| NCBI Full Name: | High affinity immunoglobulin gamma Fc receptor I |
| NCBI Synonym Full Names: | Fc fragment of IgG receptor Ia |
| NCBI Official Symbol: | FCGR1A |
| NCBI Official Synonym Symbols: | CD64; FCRI; CD64A; IGFR1 |
| NCBI Protein Information: | high affinity immunoglobulin gamma Fc receptor I |
| UniProt Protein Name: | High affinity immunoglobulin gamma Fc receptor I |
| UniProt Synonym Protein Names: | Fc-gamma RI; FcRI; Fc-gamma RIA; FcgammaRIa; CD_antigen: CD64 |
| UniProt Gene Name: | FCGR1A |
| UniProt Entry Name: | FCGR1_HUMAN |
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