Anti-FBXW11 Antibody (CAB20010)
- SKU:
- CAB20010
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-FBXW11 Antibody |
| Antibody SKU: | CAB20010 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic Peptide of human FBXW11. |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, A-431 |
| Immunogen: | A synthetic Peptide of human FBXW11. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 23291 |
| Uniprot: | Q9UKB1 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 58kDa/60kDa/62kDa |
| Observed MW: | 62kDa |
 | Western blot - FBXW11 Rabbit pAb (CAB20010) |
| Synonyms: | FBXW11, BTRC2, BTRCP2, FBW1B, FBXW1B, Fbw11, Hos |
| Background: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. |
| UniProt Protein Function: | FBW1B: a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex May participate in Wnt signaling. Three alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 5q35.1 Cellular Component: centrosome; SCF ubiquitin ligase complex; nucleus; cytosol; ubiquitin ligase complex Molecular Function:protein dimerization activity; protein binding; ubiquitin-protein ligase activity Biological Process: proteasomal ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; Wnt receptor signaling pathway; protein destabilization; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; rhythmic process; protein ubiquitination; positive regulation of circadian rhythm; negative regulation of NF-kappaB import into nucleus; protein amino acid dephosphorylation; mitotic cell cycle; G2/M transition of mitotic cell cycle; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UKB1 |
| NCBI GenInfo Identifier: | 13124267 |
| NCBI Gene ID: | 23291 |
| NCBI Accession: | Q9UKB1.1 |
| UniProt Secondary Accession: | Q9UKB1,Q9P2S8, Q9P2S9, Q9Y4C6, B2RC98, |
| UniProt Related Accession: | Q9UKB1 |
| Molecular Weight: | 60,898 Da |
| NCBI Full Name: | F-box/WD repeat-containing protein 11 |
| NCBI Synonym Full Names: | F-box and WD repeat domain containing 11 |
| NCBI Official Symbol: | FBXW11 |
| NCBI Official Synonym Symbols: | Hos; BTRC2; FBW1B; Fbw11; BTRCP2; FBXW1B |
| NCBI Protein Information: | F-box/WD repeat-containing protein 11; F-box and WD repeats protein beta-TrCP2; F-box and WD-40 domain protein 11; F-box and WD-40 domain protein 1B; F-box protein Fbw1b; F-box/WD repeat-containing protein 1B; beta-transducin repeat-containing protein 2; homologous to Slimb protein |
| UniProt Protein Name: | F-box/WD repeat-containing protein 11 |
| UniProt Synonym Protein Names: | F-box and WD repeats protein beta-TrCP2; F-box/WD repeat-containing protein 1B; Homologous to Slimb protein; HOS |
| Protein Family: | F-box/WD repeat-containing protein |
| UniProt Gene Name: | FBXW11 |
| UniProt Entry Name: | FBW1B_HUMAN |
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