Anti-FBXO8 Antibody (CAB17681)
- SKU:
- CAB17681
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| Antibody Name: | Anti-FBXO8 Antibody |
| Antibody SKU: | CAB17681 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 110-250 of human FBXO8 (NP_036312.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 110-250 of human FBXO8 (NP_036312.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GLCK STWG HCSI YNKN PPLG FSFR KLYM QLDE GSLT FNAN PDEG VNYF MSKG ILDD SPKE IAKF IFCT RTLN WKKL RIYL DERR DVLD DLVT LHNF RNQF LPNA LREF FRHI HAPE ERGE YLET LITK FSHR FCAC NPDL M |
| Gene ID: | 26269 |
| Uniprot: | Q9NRD0 |
| Cellular Location: | |
| Calculated MW: | 32kDa/37kDa |
| Observed MW: | 37kDa |
 | Western blot - FBXO8 Polyclonal Antibody (CAB17681) |
| Synonyms: | DC10, FBS, FBX8, FBXO8 |
| Background: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | FBXO8: an F-box protein that apparently mediates the ubiquitination of Arf6. May function as a guanine nucleotide exchange factor (GEF) that activates ARF G proteins. The loss of FBXO8 correlates with poor survival in hepatocellular carcinoma. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system; GEFs; GEFs, ARF Chromosomal Location of Human Ortholog: 4q34.1 |
| NCBI Summary: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NRD0 |
| NCBI GenInfo Identifier: | 13124142 |
| NCBI Gene ID: | 26269 |
| NCBI Accession: | Q9NRD0.1 |
| UniProt Secondary Accession: | Q9NRD0,Q6UWN4, Q8IWE1, Q9NRP5, Q9UKC4, B2RB40, D3DP41 G5E9Z0, |
| UniProt Related Accession: | Q9NRD0 |
| Molecular Weight: | 32,426 Da |
| NCBI Full Name: | F-box only protein 8 |
| NCBI Synonym Full Names: | F-box protein 8 |
| NCBI Official Symbol: | FBXO8 |
| NCBI Official Synonym Symbols: | FBS; DC10; FBX8 |
| NCBI Protein Information: | F-box only protein 8 |
| UniProt Protein Name: | F-box only protein 8 |
| UniProt Synonym Protein Names: | F-box/SEC7 protein FBS |
| Protein Family: | F-box only protein |
| UniProt Gene Name: | FBXO8 |
| UniProt Entry Name: | FBX8_HUMAN |
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