Anti-FBP1 Antibody (CAB11664)
- SKU:
- CAB11664
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-FBP1 Antibody |
| Antibody SKU: | CAB11664 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human FBP1 |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7 |
| Immunogen: | A synthesized peptide derived from human FBP1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2203 |
| Uniprot: | P09467 |
| Cellular Location: | |
| Calculated MW: | 37 kDa |
| Observed MW: | 40KDa |
 | Western blot - FBP1 Rabbit mAb (CAB11664) |
| Synonyms: | FBP |
| Background: | Fructose-1, 6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1, 6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1, 6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | FBPase: a key enzyme of gluconeogenesis that catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate, a precursor to glucose 6-phosphate. A regulator of glucose synthesis from non-carbohydrates. Two paralogs of this enzyme exists in humans, FBP1 in the liver and FBP2 in muscle. While both forms are inhibited allosterically by AMP, NAD and Ca2+, the muscle form is about 100-fold more sensitive to AMP and NAD, and about 1000-fold more sensitive to inhibition by Ca2+. Forms homotetramers that are stabilized in the active state by divalent cations (Mg2+, Mn2+ , Co+2, or Zn2+). Deficiency of FBP1 leads to a disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children. |
| UniProt Protein Details: | Protein type:Phosphatase (non-protein); Carbohydrate Metabolism - pentose phosphate pathway; EC 3.1.3.11; Carbohydrate Metabolism - fructose and mannose; Mitochondrial; Carbohydrate Metabolism - glycolysis and gluconeogenesis Chromosomal Location of Human Ortholog: 9q22.3 Cellular Component: cytoplasm; cytosol Molecular Function:monosaccharide binding; identical protein binding; protein binding; metal ion binding; fructose-bisphosphatase activity; AMP binding Biological Process: dephosphorylation; carbohydrate metabolic process; negative regulation of Ras protein signal transduction; glucose metabolic process; regulation of gluconeogenesis; pathogenesis; negative regulation of cell growth; negative regulation of glycolysis; fructose 6-phosphate metabolic process; protein homotetramerization; fructose metabolic process; gluconeogenesis Disease: Fructose-1,6-bisphosphatase Deficiency |
| NCBI Summary: | Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P09467 |
| NCBI GenInfo Identifier: | 311033495 |
| NCBI Gene ID: | 2203 |
| NCBI Accession: | P09467.5 |
| UniProt Secondary Accession: | P09467,O75571, Q53F94, Q96E46, |
| UniProt Related Accession: | P09467 |
| Molecular Weight: | 338 |
| NCBI Full Name: | Fructose-1,6-bisphosphatase 1 |
| NCBI Synonym Full Names: | fructose-1,6-bisphosphatase 1 |
| NCBI Official Symbol: | FBP1 |
| NCBI Official Synonym Symbols: | FBP |
| NCBI Protein Information: | fructose-1,6-bisphosphatase 1; FBPase 1; liver FBPase; fructose-bisphosphatase 1; growth-inhibiting protein 17; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 |
| UniProt Protein Name: | Fructose-1,6-bisphosphatase 1 |
| UniProt Synonym Protein Names: | D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; Liver FBPase |
| Protein Family: | Fat-body protein |
| UniProt Gene Name: | FBP1 |
| UniProt Entry Name: | F16P1_HUMAN |
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