Anti-FARS2 Antibody (CAB15246)

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SKU:
CAB15246
Product type:
Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
Frequently bought together:

Description

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Antibody Name:Anti-FARS2 Antibody
Antibody SKU:CAB15246
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human FARS2 (NP_006558.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:A549, rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human FARS2 (NP_006558.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MVGS ALRR GAHA YVYL VSKA SHIS RGHQ HQAW GSRP PAAE CATQ RAPG SVVE LLGK SYPQ DDHS NLTR KVLT RVGR NLHN QQHH PLWL IKER VKEH FYKQ YVGR FGTP LFSV YDNL SPVV TTWQ NFDS LLIP ADHP SRKK GDNY YLNR THML RAHT SAHQ WDLL HAGL DAFL VVGD VYRR DQID SQHY PIFH QLEA VRLF SKHE LFAG IKDG ESLQ LFEQ SSRS AHKQ ETHT MEAV KLVE FDLK QTLT RL
Gene ID:10667
Uniprot:O95363
Cellular Location:Mitochondrion matrix
Calculated MW:52kDa
Observed MW:52kDa
Synonyms:FARS2, COXPD14, FARS1, HSPC320, PheRS, SPG77
Background:This gene encodes a protein that transfers phenylalanine to its cognate tRNA. This protein localizes to the mitochondrion and plays a role in mitochondrial protein translation. Mutations in this gene can cause combined oxidative phosphorylation deficiency 14 (Alpers encephalopathy). Alternative splicing results in multiple transcript variants.
UniProt Protein Function:FARS2: Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins. Belongs to the class-II aminoacyl-tRNA synthetase family.
UniProt Protein Details:

Protein type:EC 6.1.1.20; RNA-binding; Translation; Mitochondrial; Ligase

Chromosomal Location of Human Ortholog: 6p25.1

Cellular Component: mitochondrial matrix

Molecular Function:phenylalanine-tRNA ligase activity; magnesium ion binding; ATP binding; tRNA binding

Biological Process: tRNA aminoacylation for protein translation; tRNA processing; phenylalanyl-tRNA aminoacylation; gene expression

Disease: Combined Oxidative Phosphorylation Deficiency 14

UniProt Code:O95363
NCBI GenInfo Identifier:15341941
NCBI Gene ID:64108
NCBI Accession:BC013161
UniProt Secondary Accession:O95363,Q9H4F3,
UniProt Related Accession:Q96DX8
Molecular Weight:27,863 Da
NCBI Full Name:Homo sapiens receptor (chemosensory) transporter protein 4, mRNA
NCBI Synonym Full Names:receptor transporter protein 4
NCBI Official Symbol:RTP4  
NCBI Official Synonym Symbols:IFRG28; Z3CXXC4  
NCBI Protein Information:receptor-transporting protein 4
UniProt Protein Name:Phenylalanine--tRNA ligase, mitochondrial
UniProt Synonym Protein Names:Phenylalanyl-tRNA synthetase; PheRS
Protein Family:Receptor-transporting protein
UniProt Gene Name:FARS2  
UniProt Entry Name:SYFM_HUMAN
Anti-FARS2 Antibody (CAB15246)Western blot analysis of extracts of various cell lines, using FARS2 antibody (CAB15246) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.

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