Anti-FANCC Antibody (CAB1812)
- SKU:
- CAB1812
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-FANCC Antibody |
| Antibody SKU: | CAB1812 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 319-558 of human FANCC (NP_000127.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, Jurkat, HeLa, Raji, Mouse small intestine |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 319-558 of human FANCC (NP_000127.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TQCF VEAL EKAS KQLR FALK TYFP YTSP SLAM VLLQ DPQD IPRG HWLQ TLKH ISEL LREA VEDQ THGS CGGP FESW FLFI HFGG WAEM VAEQ LLMS AAEP PTAL LWLL AFYY GPRD GRQQ RAQT MVQV KAVL GHLL AMSR SSSL SAQD LQTV AGQG TDTD LRAP AQQL IRHL LLNF LLWA PGGH TIAW DVIT LMAH TAEI THEI IGFL DQTL YRWN RLGI ESPR SEKL AREL LKEL RTQV |
| Gene ID: | 2176 |
| Uniprot: | Q00597 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 63kDa |
| Observed MW: | 65kDa |
| Synonyms: | FANCC, FA3, FAC, FACC |
| Background: | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C. |
| UniProt Protein Function: | FANCC: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. Defects in FANCC are the cause of Fanconi anemia complementation group C (FANCC). A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 9q22.3 Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol Molecular Function:protein binding Biological Process: removal of superoxide radicals; nucleotide-excision repair; myeloid cell homeostasis; protein complex assembly; DNA repair; germ cell development Disease: Fanconi Anemia, Complementation Group C; Tracheoesophageal Fistula With Or Without Esophageal Atresia |
| NCBI Summary: | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q00597 |
| NCBI GenInfo Identifier: | 1706762 |
| NCBI Gene ID: | 2176 |
| NCBI Accession: | Q00597.1 |
| UniProt Secondary Accession: | Q00597,B1ALR8, |
| UniProt Related Accession: | Q00597 |
| Molecular Weight: | 558 |
| NCBI Full Name: | Fanconi anemia group C protein |
| NCBI Synonym Full Names: | Fanconi anemia, complementation group C |
| NCBI Official Symbol: | FANCC |
| NCBI Official Synonym Symbols: | FA3; FAC; FACC |
| NCBI Protein Information: | Fanconi anemia group C protein |
| UniProt Protein Name: | Fanconi anemia group C protein |
| Protein Family: | Fanconi anemia group C protein |
| UniProt Gene Name: | FANCC |
| UniProt Entry Name: | FANCC_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FANCC antibody (CAB1812) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunofluorescence analysis of U2OS cells using FANCC antibody (CAB1812). Blue: DAPI for nuclear staining. |
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