Anti-FAF1 Antibody (CAB2921)
- SKU:
- CAB2921
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-FAF1 Antibody |
| Antibody SKU: | CAB2921 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human FAF1 (NP_008982.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | OVCAR3, HT-29, Mouse brain, Mouse liver, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human FAF1 (NP_008982.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MASN MDRE MILA DFQA CTGI ENID EAIT LLEQ NNWD LVAA INGV IPQE NGIL QSEY GGET IPGP AFNP ASHP ASAP TSSS SSAF RPVM PSRQ IVER QPRM LDFR VEYR DRNV DVVL EDTC TVGE IKQI LENE LQIP VSKM LLKG WKTG DVED STVL KSLH LPKN NSLY VLTP DLPP PSSS SHAG ALQE SLNQ NFML IITH REVQ REYN LNFS GSST IQEV KRNV YDLT SIPV RHQL WEGW PTSA TDDS MCLA ESGL SYPC HRLT VGRR SSPA QTRE QSEE |
| Gene ID: | 11124 |
| Uniprot: | Q9UNN5 |
| Cellular Location: | Nucleus |
| Calculated MW: | 56kDa/73kDa |
| Observed MW: | 85kDa |
| Synonyms: | FAF1, CGI-03, HFAF1s, UBXD12, UBXN3A, hFAF1 |
| Background: | Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. |
| UniProt Protein Function: | FAF1: a pro-apoptotic protein that binds to FAS antigen. Potentiates but cannot initiate FAS-induced apoptosis. Its pro-apoptotic activity requires a ubiquitin-like domain but not the FAS-binding domain. Phosphorylation by protein kinase CK2 influences transport into nucleus. Two transcript variants encoding different protein isoforms have been described. |
| UniProt Protein Details: | Protein type:Apoptosis; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 1p33 Cellular Component: perinuclear region of cytoplasm; CD95 death-inducing signaling complex; nuclear envelope; nucleus; cytosol Molecular Function:NF-kappaB binding; protein domain specific binding; protein binding; ubiquitin binding; ubiquitin protein ligase binding; heat shock protein binding; protein kinase regulator activity; protein kinase binding Biological Process: regulation of cell adhesion; cell death; proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein complex assembly; cytoplasmic sequestering of NF-kappaB; positive regulation of apoptosis; apoptosis; regulation of protein catabolic process; regulation of protein kinase activity |
| NCBI Summary: | Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UNN5 |
| NCBI GenInfo Identifier: | 20454906 |
| NCBI Gene ID: | 11124 |
| NCBI Accession: | Q9UNN5.2 |
| UniProt Secondary Accession: | Q9UNN5,Q549F0, Q9UF34, Q9UNT3, Q9Y2Z3, |
| UniProt Related Accession: | Q9UNN5 |
| Molecular Weight: | 650 |
| NCBI Full Name: | FAS-associated factor 1 |
| NCBI Synonym Full Names: | Fas (TNFRSF6) associated factor 1 |
| NCBI Official Symbol: | FAF1 |
| NCBI Official Synonym Symbols: | hFAF1; CGI-03; HFAF1s; UBXD12; UBXN3A |
| NCBI Protein Information: | FAS-associated factor 1; UBX domain protein 3A; TNFRSF6-associated factor 1; UBX domain-containing protein 12; UBX domain-containing protein 3A |
| UniProt Protein Name: | FAS-associated factor 1 |
| UniProt Synonym Protein Names: | UBX domain-containing protein 12; UBX domain-containing protein 3A |
| Protein Family: | FAS-associated factor |
| UniProt Gene Name: | FAF1 |
| UniProt Entry Name: | FAF1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FAF1 antibody (CAB2921) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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