Anti-FADS3 Antibody (CAB3947)
- SKU:
- CAB3947
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-FADS3 Antibody |
| Antibody SKU: | CAB3947 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human FADS3 (NP_068373.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse kidney, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human FADS3 (NP_068373.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGGV GEPG PREG PAQP GAPL PTFC WEQI RAHD QPGD KWLV IERR VYDI SRWA QRHP GGSR LIGH HGAE DATD AFRA FHQD LNFV RKFL QPLL IGEL APEE PSQD GPLN AQLV EDFR ALHQ AAED MKLF DA |
| Gene ID: | 3995 |
| Uniprot: | Q9Y5Q0 |
| Cellular Location: | Endoplasmic reticulum membrane, Multi-pass membrane protein |
| Calculated MW: | 51kDa |
| Observed MW: | 55kDa |
| Synonyms: | FADS3, CYB5RP, LLCDL3 |
| Background: | The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. |
| UniProt Protein Function: | FADS3: is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; EC 1.14.19.-; Membrane protein, integral; Oxidoreductase Chromosomal Location of Human Ortholog: 11q12-q13.1 Cellular Component: endoplasmic reticulum membrane; membrane; integral to membrane Molecular Function:iron ion binding; heme binding; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water Biological Process: unsaturated fatty acid biosynthetic process |
| NCBI Summary: | The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y5Q0 |
| NCBI GenInfo Identifier: | 74762790 |
| NCBI Gene ID: | 3995 |
| NCBI Accession: | Q9Y5Q0.1 |
| UniProt Secondary Accession: | Q9Y5Q0,O60426, |
| UniProt Related Accession: | Q9Y5Q0 |
| Molecular Weight: | 445 |
| NCBI Full Name: | Fatty acid desaturase 3 |
| NCBI Synonym Full Names: | fatty acid desaturase 3 |
| NCBI Official Symbol: | FADS3 |
| NCBI Official Synonym Symbols: | CYB5RP; LLCDL3 |
| NCBI Protein Information: | fatty acid desaturase 3; delta-9-desaturase; cytochrome b5-related protein; delta-9 fatty acid desaturase; linoleoyl-CoA desaturase (delta-9-desaturase)-like 3 |
| UniProt Protein Name: | Fatty acid desaturase 3 |
| UniProt Synonym Protein Names: | Cytochrome b5-related protein |
| Protein Family: | Fatty acid desaturase |
| UniProt Gene Name: | FADS3 |
| UniProt Entry Name: | FADS3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FADS3 antibody (CAB3947) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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