Anti-FADD Antibody (CAB19838)

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SKU:
CAB19838
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
Mort1/FADD
Frequently bought together:

Description

Product Name:FADD Rabbit mAb
Product Code:CAB19838
Size:20uL, 50uL, 100uL
Synonyms:Mort1/FADD
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human FADD
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:NIH/3T3, Mouse brain, Mouse thymus
Immunogen:A synthesized peptide derived from human FADD
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:14082
Uniprot:Q61160
Calculated MW:28kDa
Observed MW:28KDa
UniProt Protein Function:FADD: an adaptor molecule that mediates apoptosis. Recruited through its C-terminal death domain by Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TRAIL-receptor, participating in the death signaling initiated by these receptors. Interaction with the receptors unmasks the N-terminal effector domain of this protein, which recruits caspase-8, and thereby activates the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
UniProt Protein Details:

Protein type:Adaptor/scaffold; Apoptosis

Cellular Component: CD95 death-inducing signaling complex; cytoplasm; cytosol; lipid raft; neuron projection; plasma membrane; protein complex

Molecular Function:death receptor binding; identical protein binding; protease binding; protein binding; protein complex binding; tumor necrosis factor receptor binding; tumor necrosis factor receptor superfamily binding

Biological Process: apoptosis; cardiac muscle development; defense response to virus; innate immune response; lymph node development; positive regulation of activated T cell proliferation; positive regulation of adaptive immune response; positive regulation of apoptosis; positive regulation of interferon-gamma production; positive regulation of interleukin-8 production; positive regulation of macrophage differentiation; positive regulation of proteolysis; positive regulation of T cell mediated cytotoxicity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; protein heterooligomerization; spleen development; T cell differentiation; T cell differentiation in the thymus; T cell homeostasis; thymus development

UniProt Code:Q61160
NCBI GenInfo Identifier:2498356
NCBI Gene ID:14082
NCBI Accession:Q61160.1
UniProt Secondary Accession:Q61160,Q3TC37, Q61082,
UniProt Related Accession:Q61160
Molecular Weight:22,960 Da
NCBI Full Name:FAS-associated death domain protein
NCBI Synonym Full Names:Fas (TNFRSF6)-associated via death domain
NCBI Official Symbol:Fadd  
NCBI Official Synonym Symbols:Mort1/FADD  
NCBI Protein Information:FAS-associated death domain protein
UniProt Protein Name:FAS-associated death domain protein
UniProt Synonym Protein Names:FAS-associating death domain-containing protein; Mediator of receptor induced toxicity; Protein FADD
Protein Family:Fas-associated death domain protein
UniProt Gene Name:Fadd  
UniProt Entry Name:FADD_MOUSE

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