Anti-FAAH Antibody (CAB1174)
- SKU:
- CAB1174
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-FAAH Antibody |
| Antibody SKU: | CAB1174 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 450-579 of human FAAH (NP_001432.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HT-29, SW620, Mouse brain, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 450-579 of human FAAH (NP_001432.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EIEV YRKT VIAQ WRAL DLDV VLTP MLAP ALDL NAPG RATG AVSY TMLY NCLD FPAG VVPV TTVT AEDE AQME HYRG YFGD IWDK MLQK GMKK SVGL PVAV QCVA LPWQ EELC LRFM REVE RLMT PEKQ SS |
| Gene ID: | 2166 |
| Uniprot: | O00519 |
| Cellular Location: | Cytoplasm, Endomembrane system, Single-pass membrane protein, cytoskeleton |
| Calculated MW: | 63kDa |
| Observed MW: | 60kDa |
| Synonyms: | FAAH, FAAH-1, PSAB |
| Background: | This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. |
| UniProt Protein Function: | FAAH: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. Homodimer. Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate. Inhibited by O-aryl carbamates and alpha-keto heterocytes. Belongs to the amidase family. |
| UniProt Protein Details: | Protein type:EC 3.5.1.99; Membrane protein, integral; Hydrolase Chromosomal Location of Human Ortholog: 1p35-p34 Cellular Component: cytoskeleton; cytoplasm; integral to membrane; endomembrane system Molecular Function:fatty acid amide hydrolase activity; carbon-nitrogen ligase activity, with glutamine as amido-N-donor; acylglycerol lipase activity Biological Process: fatty acid catabolic process Disease: Polysubstance Abuse, Susceptibility To |
| NCBI Summary: | This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00519 |
| NCBI GenInfo Identifier: | 60416391 |
| NCBI Gene ID: | 2166 |
| NCBI Accession: | O00519.2 |
| UniProt Related Accession: | O00519 |
| Molecular Weight: | ~ 63kDa |
| NCBI Full Name: | Fatty-acid amide hydrolase 1 |
| NCBI Synonym Full Names: | fatty acid amide hydrolase |
| NCBI Official Symbol: | FAAH |
| NCBI Official Synonym Symbols: | PSAB; FAAH-1 |
| NCBI Protein Information: | fatty-acid amide hydrolase 1 |
| UniProt Protein Name: | Fatty-acid amide hydrolase 1 |
| UniProt Synonym Protein Names: | Anandamide amidohydrolase 1; Oleamide hydrolase 1 |
| Protein Family: | Fatty-acid amide hydrolase |
| UniProt Gene Name: | FAAH |
| UniProt Entry Name: | FAAH1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FAAH antibody (CAB1174) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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