Anti-F2RL3 Antibody (CAB8471)

(No reviews yet) Write a Review
SKU:
CAB8471
Product type:
Antibody
Application:
WB
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cardiovascular
Frequently bought together:

Description

system_update_alt데이터시트system_update_alt안전 데이터시트
Antibody Name:Anti-F2RL3 Antibody
Antibody SKU:CAB8471
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-150 of human F2RL3 (NP_003941.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, HT-29, Raji, B cells, Mouse spleen, Mouse lung, Mouse skeletal muscle, Rat spleen
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-150 of human F2RL3 (NP_003941.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TQTP SVYD ESGS TGGG DDST PSIL PAPR GYPG QVCA NDSD TLEL PDSS RALL LGWV PTRL VPAL YGLV LVVG LPAN GLAL WVLA TQAP RLPS TMLL MNLA AADL LLAL ALPP RIAY HLRG QRWP FGEA ACR
Gene ID:9002
Uniprot:Q96RI0
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:41kDa
Observed MW:41kDa
Synonyms:F2RL3, PAR4
Background:Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.
UniProt Protein Function:PAR4: a G-protein coupled receptor for activated thrombin or trypsin. Coupled to G proteins that stimulate phosphoinositide hydrolysis. Plays a role in platelets activation. Thrombin requires PAR4 for full spreading on a fibrinogen matrix. Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets. A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
UniProt Protein Details:

Protein type:Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 19p12

Cellular Component: extracellular region; integral to plasma membrane; plasma membrane

Molecular Function:thrombin receptor activity

Biological Process: blood coagulation; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); platelet activation; platelet dense granule organization and biogenesis; positive regulation of release of sequestered calcium ion into cytosol; response to wounding; signal transduction

NCBI Summary:Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin. [provided by RefSeq, Jul 2008]
UniProt Code:Q96RI0
NCBI GenInfo Identifier:116242700
NCBI Gene ID:9002
NCBI Accession:Q96RI0.3
UniProt Secondary Accession:Q96RI0,O76067, Q6DK42,
UniProt Related Accession:Q96RI0
Molecular Weight:41,133 Da
NCBI Full Name:Proteinase-activated receptor 4
NCBI Synonym Full Names:F2R like thrombin/trypsin receptor 3
NCBI Official Symbol:F2RL3  
NCBI Official Synonym Symbols:PAR4  
NCBI Protein Information:proteinase-activated receptor 4
UniProt Protein Name:Proteinase-activated receptor 4
UniProt Synonym Protein Names:Coagulation factor II receptor-like 3; Thrombin receptor-like 3
Protein Family:Proteinase-activated receptor
UniProt Gene Name:F2RL3  
UniProt Entry Name:PAR4_HUMAN
Anti-F2RL3 Polyclonal Antibody (CAB8471)Western blot analysis of extracts of various cell lines, using F2RL3 antibody (CAB8471) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

0 Reviews

View AllClose

Related Products