Anti-EXTL2 Antibody (CAB15669)
- SKU:
- CAB15669
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-EXTL2 Antibody |
| Antibody SKU: | CAB15669 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 41-330 of human EXTL2 (NP_001430.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 41-330 of human EXTL2 (NP_001430.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PSVK EDKM LMLR REIK SQGK STMD SFTL IMQT YNRT DLLL KLLN HYQA VPNL HKVI VVWN NIGE KAPD ELWN SLGP HPIP VIFK QQTA NRMR NRLQ VFPE LETN AVLM VDDD TLIS TPDL VFAF SVWQ QFPD QIVG FVPR KHVS TSSG IYSY GSFE MQAP GSGN GDQY SMVL IGAS FFNS KYLE LFQR QPAA VHAL IDDT QNCD DIAM NFII AKHI GKTS GIFV KPVN MDNL EKET NSGY SGMW HRAE HALQ RSYC INKL VNIY DSMP LRYS NIMI SQFG FPYA NYKR KI |
| Gene ID: | 2135 |
| Uniprot: | Q9UBQ6 |
| Cellular Location: | Endoplasmic reticulum membrane, Secreted, Single-pass type II membrane protein |
| Calculated MW: | 37kDa |
| Observed MW: | 37kDa |
| Synonyms: | EXTL2, EXTR2 |
| Background: |
| UniProt Protein Function: | EXTL2: Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N- acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Belongs to the glycosyltransferase 47 family. |
| UniProt Protein Details: | Protein type:Transferase; Glycan Metabolism - heparan sulfate biosynthesis; EC 2.4.1.223; Membrane protein, integral Chromosomal Location of Human Ortholog: 1p21 Cellular Component: endoplasmic reticulum Molecular Function:alpha-1,4-N-acetylgalactosaminyltransferase activity; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity Biological Process: N-acetylglucosamine metabolic process; UDP-N-acetylgalactosamine metabolic process |
| UniProt Code: | Q9UBQ6 |
| NCBI GenInfo Identifier: | 9296986 |
| NCBI Gene ID: | 2135 |
| NCBI Accession: | Q9UBQ6.1 |
| UniProt Secondary Accession: | Q9UBQ6,B2R795, D3DT60, |
| UniProt Related Accession: | Q9UBQ6 |
| Molecular Weight: | 37,466 Da |
| NCBI Full Name: | Exostosin-like 2 |
| NCBI Synonym Full Names: | exostosin like glycosyltransferase 2 |
| NCBI Official Symbol: | EXTL2 |
| NCBI Official Synonym Symbols: | EXTR2 |
| NCBI Protein Information: | exostosin-like 2 |
| UniProt Protein Name: | Exostosin-like 2 |
| UniProt Synonym Protein Names: | Alpha-1,4-N-acetylhexosaminyltransferase EXTL2; Alpha-GalNAcT EXTL2; EXT-related protein 2; Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase |
| Protein Family: | Exostosin |
| UniProt Gene Name: | EXTL2 |
| UniProt Entry Name: | EXTL2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using EXTL2 antibody (CAB15669) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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