Anti-Exportin 5 Antibody (CAB3813)
- SKU:
- CAB3813
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
| Antibody Name: | Anti-Exportin 5 Antibody |
| Antibody SKU: | CAB3813 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Exportin 5 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain, Mouse kidney, Rat brain, U2OS, MCF7, U-251MG |
| Immunogen: | A synthesized peptide derived from human Exportin 5 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 57510 |
| Uniprot: | Q9HAV4 |
| Cellular Location: | |
| Calculated MW: | 136kDa |
| Observed MW: | 136KDa |
| Synonyms: | exp5 |
| Background: | This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011] |
| UniProt Protein Function: | Exportin-5: mediates the nuclear export of proteins bearing double-stranded RNA binding domains and double-stranded RNA. Overexpression enhances RNA interference mediated by shRNAs and miRNAs. In the nucleus it binds cooperatively to its cargo and to Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. Exp5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. Two isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nuclear export; Karyopherin; Nuclear import; RNA-binding Chromosomal Location of Human Ortholog: 6p21.1 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:mRNA binding; protein binding; Ran GTPase binding; RNA binding Biological Process: pre-microRNA export from nucleus; protein export from nucleus; RNA-mediated gene silencing |
| NCBI Summary: | This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q9HAV4 |
| NCBI GenInfo Identifier: | 74734245 |
| NCBI Gene ID: | 57510 |
| NCBI Accession: | Q9HAV4.1 |
| UniProt Secondary Accession: | Q9HAV4,Q5JTE6, Q96G48, Q96HN3, Q9BWM6, Q9BZV5, Q9H9M4 Q9NT89, Q9NW39, Q9ULC9, |
| UniProt Related Accession: | Q9HAV4 |
| Molecular Weight: | 136,311 Da |
| NCBI Full Name: | Exportin-5 |
| NCBI Synonym Full Names: | exportin 5 |
| NCBI Official Symbol: | XPO5 |
| NCBI Official Synonym Symbols: | exp5 |
| NCBI Protein Information: | exportin-5 |
| UniProt Protein Name: | Exportin-5 |
| UniProt Synonym Protein Names: | Ran-binding protein 21 |
| Protein Family: | Exportin |
| UniProt Gene Name: | XPO5 |
| UniProt Entry Name: | XPO5_HUMAN |
 | Western blot - Exportin 5 Rabbit mAb (CAB3813) |
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