Anti-Exportin 2 (XPO2) Antibody (CAB1041)

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SKU:
CAB1041
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CAS
CSE1
XPO2
Frequently bought together:

Description

Product Name:Exportin 2 (XPO2) Rabbit mAb
Product Code:CAB1041
Size:20uL, 50uL, 100uL
Synonyms:CAS, CSE1, XPO2
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Exportin 2 (XPO2)
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa, 293T, Jurkat, Mouse testis, Mouse thymus
Immunogen:A synthesized peptide derived from human Exportin 2 (XPO2)
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1434
Uniprot:P55060
Cellular Location:Cytoplasm, Nucleus
Calculated MW:98kDa
Observed MW:105kDa
UniProt Protein Function:Exportin-2: Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the XPO2/CSE1 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Nuclear export; Karyopherin; Nuclear import

Chromosomal Location of Human Ortholog: 20q13

Cellular Component: cytoplasm; cytosol; membrane; nuclear envelope; nucleoplasm; nucleus

Molecular Function:nuclear export signal receptor activity; protein binding

Biological Process: apoptosis; cell proliferation; protein import into nucleus

NCBI Summary:Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Code:P55060
NCBI GenInfo Identifier:62297557
NCBI Gene ID:1434
NCBI Accession:P55060.3
UniProt Secondary Accession:P55060,O75432, Q32M40, Q9H5B7, Q9NTS0, Q9UP98, Q9UP99 Q9UPA0, A3RLL6, B2R5T4, E1P5Y0, F8W904,
UniProt Related Accession:P55060
Molecular Weight:103,879 Da
NCBI Full Name:Exportin-2
NCBI Synonym Full Names:chromosome segregation 1 like
NCBI Official Symbol:CSE1L  
NCBI Official Synonym Symbols:CAS; CSE1; XPO2  
NCBI Protein Information:exportin-2
UniProt Protein Name:Exportin-2
UniProt Synonym Protein Names:Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; Importin-alpha re-exporter
UniProt Gene Name:CSE1L  
UniProt Entry Name:XPO2_HUMAN

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