Anti-EXOSC8 Antibody (CAB4507)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- CAB4507
- Product type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- EXOSC8
- Synonyms:
- CIP3
- Synonyms:
- EAP2
- Synonyms:
- OIP2
- Synonyms:
- PCH1C
- Synonyms:
- RRP43
- Synonyms:
- Rrp43p
- Synonyms:
- bA421P11.3
- Synonyms:
- p9
Frequently bought together:
Description
| Product Name: | EXOSC8 Rabbit pAb |
| Product Code: | CAB4507 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | EXOSC8, CIP3, EAP2, OIP2, PCH1C, RRP43, Rrp43p, bA421P11.3, p9 |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-276 of human EXOSC8 (NP_852480.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HeLa, HL-60, MCF7, SW480 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-276 of human EXOSC8 (NP_852480.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAG FKTV EPLE YYRR FLKE NCRP DGRE LGEF RTTT VNIG SIST ADGS ALVK LGNT TVIC GVKA EFAA PSTD APDK GYVV PNVD LPPL CSSR FRSG PPGE EAQV ASQF IADV IENS QIIQ KEDL CISP GKLV WVLY CDLI CLDY DGNI LDAC TFAL LAAL KNVQ LPEV TINE ETAL AEVN LKKK SYLN IRTH PVAT SFAV FDDT LLIV DPTG EEEH LATG TLTI VMDE EGKL CCLH KPGG SGLT GAKL QDCM SRAV TRHK EVKK LMDE VIKS MKPK |
| Gene ID: | 11340 |
| Uniprot: | Q96B26 |
| Cellular Location: | Cytoplasm, Nucleus, nucleolus |
| Calculated MW: | 30kDa |
| Observed MW: | 35kDa |
| UniProt Protein Function: | EXOSC8: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs. Belongs to the RNase PH family. |
| UniProt Protein Details: | Protein type:Nucleolus; EC 3.1.13.-; Ribonuclease Chromosomal Location of Human Ortholog: 13q13.1 Cellular Component: cytoplasm; nucleolus; exosome (RNase complex); nucleus; cytosol Molecular Function:protein binding; exoribonuclease activity; AU-rich element binding Biological Process: gene expression; rRNA processing; mRNA catabolic process, deadenylation-dependent decay Disease: Pontocerebellar Hypoplasia, Type 1c |
| NCBI Summary: | This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2009] |
| UniProt Code: | Q96B26 |
| NCBI GenInfo Identifier: | 21759409 |
| NCBI Gene ID: | 11340 |
| NCBI Accession: | Q96B26.1 |
| UniProt Secondary Accession: | Q96B26,O43480, Q5TBA5, |
| UniProt Related Accession: | Q96B26 |
| Molecular Weight: | 276 |
| NCBI Full Name: | Exosome complex component RRP43 |
| NCBI Synonym Full Names: | exosome component 8 |
| NCBI Official Symbol: | EXOSC8 |
| NCBI Official Synonym Symbols: | p9; CIP3; EAP2; OIP2; PCH1C; RRP43; Rrp43p; bA421P11.3 |
| NCBI Protein Information: | exosome complex component RRP43; OIP-2; CBP-interacting protein 3; Opa interacting protein 2; opa-interacting protein 2; exosome complex exonuclease RRP43; ribosomal RNA-processing protein 43 |
| UniProt Protein Name: | Exosome complex component RRP43 |
| UniProt Synonym Protein Names: | Exosome component 8; Opa-interacting protein 2; OIP-2; Ribosomal RNA-processing protein 43; p9 |
| Protein Family: | Exosome complex component |
| UniProt Gene Name: | EXOSC8 |
| UniProt Entry Name: | EXOS8_HUMAN |
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