Anti-EXOC4 Antibody (CAB12374)
- SKU:
- CAB12374
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-EXOC4 Antibody |
| Antibody SKU: | CAB12374 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human EXOC4 (NP_068579.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-431, Jurkat, Mouse brain, Mouse thymus, Mouse liver, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human EXOC4 (NP_068579.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAE AAGG KYRS TVSK SKDP SGLL ISVI RTLS TSDD VEDR ENEK GRLE EAYE KCDR DLDE LIVQ HYTE LTTA IRTY QSIT ERIT NSRN KIKQ VKEN LLSC KMLL HCKR DELR KLWI EGIE HKHV LNLL DEIE NIKQ VPQK LEQC MASK HYLS ATDM LVSA VESL EGPL LQVE GLSD LRLE LHSK KMNL HLVL IDEL HRHL YIKS TSRV VQRN KEKG KISS LVKD ASVP LIDV TNLP TPRK FLDT SHYS TAGS SSVR EINL QDIK EDLE LDPE ENST LFMG |
| Gene ID: | 60412 |
| Uniprot: | Q96A65 |
| Cellular Location: | |
| Calculated MW: | 53kDa/110kDa |
| Observed MW: | 122kDa |
| Synonyms: | EXOC4, SEC8, SEC8L1, Sec8p |
| Background: | The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
| UniProt Protein Function: | EXOC4: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC8 family. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 7q31 Cellular Component: cytoplasm; cytosol; membrane; plasma membrane Molecular Function:protein binding; protein N-terminus binding; Ral GTPase binding Biological Process: regulation of macroautophagy |
| NCBI Summary: | The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96A65 |
| NCBI GenInfo Identifier: | 24418674 |
| NCBI Gene ID: | 60412 |
| NCBI Accession: | Q96A65.1 |
| UniProt Secondary Accession: | Q96A65,Q541U8, Q9C0G4, Q9H9K0, Q9P102, E9PED2, |
| UniProt Related Accession: | Q96A65 |
| Molecular Weight: | 53,857 Da |
| NCBI Full Name: | Exocyst complex component 4 |
| NCBI Synonym Full Names: | exocyst complex component 4 |
| NCBI Official Symbol: | EXOC4 |
| NCBI Official Synonym Symbols: | SEC8; Sec8p; SEC8L1 |
| NCBI Protein Information: | exocyst complex component 4 |
| UniProt Protein Name: | Exocyst complex component 4 |
| UniProt Synonym Protein Names: | Exocyst complex component Sec8 |
| UniProt Gene Name: | EXOC4 |
| UniProt Entry Name: | EXOC4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using EXOC4 antibody (CAB12374) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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