Anti-EVPL Antibody (CAB10215)

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SKU:
CAB10215
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-EVPL Antibody
Antibody SKU:CAB10215
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1784-2033 of human EVPL (NP_001979.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, Mouse lung, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1784-2033 of human EVPL (NP_001979.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TKPS SSLS IGSI ISKS PLAS PAPQ STSF FSPS FSLG LGDD SFPI AGIY DTTT DNKC SIKT AVAK NMLD PITG QKLL EAQA ATGG IVDL LSRE RYSV HKAM ERGL IENT STQR LLNA QKAF TGIE DPVT KKRL SVGE AVQK GWMP RESV LPHL QVQH LTGG LIDP KRTG RIPI QQAL LSGM ISEE LAQL LQDE SSYE KDLT DPIS KERL SYKE AMGR CRKD PLSG LLLL PAAL EGYR CYRS ASPT VPRS LR
Gene ID:2125
Uniprot:Q92817
Cellular Location:Cell junction, Cornified envelope, Cytoplasm, cytoskeleton, desmosome
Calculated MW:231kDa
Observed MW:270kDa
Synonyms:EVPL, EVPK
Background:This gene encodes a member of the plakin family of proteins that forms a component of desmosomes and the epidermal cornified envelope. This gene is located in the tylosis oesophageal cancer locus on chromosome 17q25, and its deletion is associated with both familial and sporadic forms of oesophageal squamous cell carcinoma. Patients suffering from the autoimmune mucocutaneous disorder, paraneoplastic pemphigus, develop antibodies against the encoded protein.
UniProt Protein Function:envoplakin: Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. Belongs to the plakin or cytolinker family.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17q25.1

Cellular Component: cornified envelope; cytosol; intermediate filament cytoskeleton

Molecular Function:cadherin binding; protein binding, bridging; structural molecule activity

Biological Process: epidermis development; keratinocyte differentiation; peptide cross-linking

NCBI Summary:This gene encodes a member of the plakin family of proteins that forms a component of desmosomes and the epidermal cornified envelope. This gene is located in the tylosis oesophageal cancer locus on chromosome 17q25, and its deletion is associated with both familial and sporadic forms of oesophageal squamous cell carcinoma. Patients suffering from the autoimmune mucocutaneous disorder, paraneoplastic pemphigus, develop antibodies against the encoded protein. [provided by RefSeq, Jul 2016]
UniProt Code:Q92817
NCBI GenInfo Identifier:296439359
NCBI Gene ID:2125
NCBI Accession:Q92817.3
UniProt Secondary Accession:Q92817,A0AUV5,
UniProt Related Accession:Q92817
Molecular Weight:232kDa
NCBI Full Name:Envoplakin
NCBI Synonym Full Names:envoplakin
NCBI Official Symbol:EVPL  
NCBI Official Synonym Symbols:EVPK  
NCBI Protein Information:envoplakin
UniProt Protein Name:Envoplakin
UniProt Synonym Protein Names:210 kDa cornified envelope precursor protein; 210 kDa paraneoplastic pemphigus antigen; p210
Protein Family:Envoplakin
UniProt Gene Name:EVPL  
Anti-EVPL Antibody (CAB10215)Western blot analysis of extracts of various cell lines, using EVPL antibody (CAB10215) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

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