Anti-Estrogen Related Receptor alpha Antibody (CAB4176)

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SKU:
CAB4176
Product type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
Frequently bought together:

Description

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Antibody Name:Anti-Estrogen Related Receptor alpha Antibody
Antibody SKU:CAB4176
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Estrogen Related Receptor alpha
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa, 293T, Mouse brain
Immunogen:A synthesized peptide derived from human Estrogen Related Receptor alpha
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2101
Uniprot:P11474
Cellular Location:
Calculated MW:55kDa
Observed MW:50KDa
Synonyms:ERR1, ERRa, ERRalpha, ESRL1, NR3B1
Background:The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]
UniProt Protein Function:ERR1: Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Belongs to the nuclear hormone receptor family. NR3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Nuclear receptor

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: microtubule cytoskeleton; nucleoplasm; intercellular bridge; nucleolus; nucleus

Molecular Function:protein domain specific binding; ligand-dependent nuclear receptor activity; protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; steroid binding

Biological Process: transcription initiation from RNA polymerase II promoter; mitochondrion organization and biogenesis; intracellular receptor-mediated signaling pathway; regulation of osteoblast differentiation; organelle organization and biogenesis; negative regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; regulation of osteoclast differentiation; regulation of transcription, DNA-dependent; cartilage development; gene expression; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter

NCBI Summary:The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]
UniProt Code:P11474
NCBI GenInfo Identifier:215274146
NCBI Gene ID:2101
NCBI Accession:P11474.3
UniProt Related Accession:P11474
Molecular Weight:
NCBI Full Name:Steroid hormone receptor ERR1
NCBI Synonym Full Names:estrogen related receptor alpha
NCBI Official Symbol:ESRRA  
NCBI Official Synonym Symbols:ERR1; ERRa; ESRL1; NR3B1; ERRalpha  
NCBI Protein Information:steroid hormone receptor ERR1
UniProt Protein Name:Steroid hormone receptor ERR1
UniProt Synonym Protein Names:Estrogen receptor-like 1; Estrogen-related receptor alpha; ERR-alpha; Nuclear receptor subfamily 3 group B member 1
Protein Family:Enolase-related protein
UniProt Gene Name:ESRRA  
UniProt Entry Name:ERR1_HUMAN
Anti-Estrogen Related Receptor alpha Antibody (CAB4176)Western blot - Estrogen Related Receptor alpha Rabbit mAb (CAB4176)

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