Anti-ERP44 Antibody (CAB4526)

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SKU:
CAB4526
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ERP44
PDIA10
TXNDC4
Frequently bought together:

Description

Product Name:ERP44 Rabbit pAb
Product Code:CAB4526
Size:20uL, 50uL, 100uL
Synonyms:ERP44, PDIA10, TXNDC4
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 57-406 of human ERP44 (NP_055866.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, U-87MG, HepG2, Mouse kidney, Rat Pancreas
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 57-406 of human ERP44 (NP_055866.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:WCRF SQML HPIF EEAS DVIK EEFP NENQ VVFA RVDC DQHS DIAQ RYRI SKYP TLKL FRNG MMMK REYR GQRS VKAL ADYI RQQK SDPI QEIR DLAE ITTL DRSK RNII GYFE QKDS DNYR VFER VANI LHDD CAFL SAFG DVSK PERY SGDN IIYK PPGH SAPD MVYL GAMT NFDV TYNW IQDK CVPL VREI TFEN GEEL TEEG LPFL ILFH MKED TESL EIFQ NEVA RQLI SEKG TINF LHAD CDKF RHPL LHIQ KTPA DCPV IAID SFRH MYVF GDFK DVLI PGKL KQFV FDLH SGKL HREF HHGP DPTD TAPG EQAQ DVAS SPPE SSFQ KLAP SEYR YTLL RDRD EL
Gene ID:23071
Uniprot:Q9BS26
Cellular Location:Endoplasmic reticulum lumen
Calculated MW:46kDa
Observed MW:40-48kDa
UniProt Protein Function:ERP44: Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum. Forms mixed disulfides with both ERO1L and ERO1LB and cargo folding intermediates. Directly interacts with ITPR1 in a pH-, redox state- and calcium-dependent manner, but not with ITPR2 or ITPR3. The strength of this interaction inversely correlates with calcium concentration. By endoplasmic reticulum stress.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Endoplasmic reticulum; Secreted; Isomerase

Chromosomal Location of Human Ortholog: 9q31.1

Cellular Component: endoplasmic reticulum membrane; cell surface; endoplasmic reticulum lumen; ER-Golgi intermediate compartment

Molecular Function:protein binding; protein disulfide isomerase activity

Biological Process: glycoprotein metabolic process; protein folding; cell redox homeostasis; response to unfolded protein

NCBI Summary:This gene encodes a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-retention sequence. This protein functions as a pH-regulated chaperone of the secretory pathway and likely plays a role in protein quality control at the endoplasmic reticulum - Golgi interface. [provided by RefSeq, Dec 2016]
UniProt Code:Q9BS26
NCBI GenInfo Identifier:31077035
NCBI Gene ID:23071
NCBI Accession:Q9BS26.1
UniProt Related Accession:Q9BS26
Molecular Weight:47kDa
NCBI Full Name:Endoplasmic reticulum resident protein 44
NCBI Synonym Full Names:endoplasmic reticulum protein 44
NCBI Official Symbol:ERP44  
NCBI Official Synonym Symbols:PDIA10; TXNDC4  
NCBI Protein Information:endoplasmic reticulum resident protein 44
UniProt Protein Name:Endoplasmic reticulum resident protein 44
UniProt Synonym Protein Names:Thioredoxin domain-containing protein 4
Protein Family:Endoplasmic reticulum resident protein
UniProt Gene Name:ERP44  
UniProt Entry Name:ERP44_HUMAN

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