Anti-ERBB4 Antibody (CAB6133)
- SKU:
- CAB6133
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-ERBB4 Antibody |
| Antibody SKU: | CAB6133 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-160 of human ERBB4 (NP_005226.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:1000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-160 of human ERBB4 (NP_005226.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QSVC AGTE NKLS SLSD LEQQ YRAL RKYY ENCE VVMG NLEI TSIE HNRD LSFL RSVR EVTG YVLV ALNQ FRYL PLEN LRII RGTK LYED RYAL AIFL NYRK DGNF GLQE LGLK NLTE ILNG GVYV DQNK FLCY ADT |
| Gene ID: | 2066 |
| Uniprot: | Q15303 |
| Cellular Location: | Cell membrane, Mitochondrion, Nucleus, Single-pass type I membrane protein |
| Calculated MW: | 143kDa/145kDa/146kDa |
| Observed MW: | 180kDa |
| Synonyms: | ALS19, HER4, p180erbB4, ERBB4, HER4/ErbB4 |
| Background: | This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. |
| NCBI Summary: | This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15303 |
| NCBI GenInfo Identifier: | 3913590 |
| NCBI Gene ID: | 2066 |
| NCBI Accession: | |
| UniProt Related Accession: | Q15303 |
| Molecular Weight: | |
| NCBI Full Name: | Receptor tyrosine-protein kinase erbB-4 |
| NCBI Synonym Full Names: | erb-b2 receptor tyrosine kinase 4 |
| NCBI Official Symbol: | ERBB4 |
| NCBI Official Synonym Symbols: | HER4; ALS19; p180erbB4 |
| NCBI Protein Information: | receptor tyrosine-protein kinase erbB-4 |
| UniProt Protein Name: | |
| UniProt Gene Name: |
 | Western blot analysis of extracts of mouse brain, using ERBB4 antibody (CAB6133) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded human placenta using ERBB4 Rabbit pAb (CAB6133) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of C6 cells using ERBB4 Rabbit pAb (CAB6133) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of NIH-3T3 cells using ERBB4 Rabbit pAb (CAB6133) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of U-2 OS cells using ERBB4 Rabbit pAb (CAB6133) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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