Anti-EPC1 Antibody (CAB5807)
- SKU:
- CAB5807
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| Antibody Name: | Anti-EPC1 Antibody |
| Antibody SKU: | CAB5807 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human EPC1 (NP_079485.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | THP-1, Mouse lung, Mouse ovary |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human EPC1 (NP_079485.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSKL SFRA RALD ASKP LPVF RCED LPDL HEYA SINR AVPQ MPTG MEKE EESE HHLQ RAIS AQQV YGEK RDNM VIPV PEAE SNIA YYES IYPG EFKM PKQL IHIQ PFSL DAEQ PDYD LDSE DEVF VNKL KKKM DICP LQFE EMID RLEK GSGQ QPVS LQEA KLLL KEDD ELIR EVYE YWIK KRKN CRGP SLIP SVKQ EKRD GSST NDPY VAFR RRTE KMQT RKNR KNDE ASYE KMLK LRRD LSRA VTIL EMIK RREK SKRE LLHL TLEI MEKR YNLG DYNG EIMS EVMA QRQP MKPT YAIP |
| Gene ID: | 80314 |
| Uniprot: | Q9H2F5 |
| Cellular Location: | Nucleus |
| Calculated MW: | 85kDa/90kDa/93kDa |
| Observed MW: | 105kDa |
| Synonyms: | EPC1, Epl1 |
| Background: | This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | EPC1: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Belongs to the enhancer of polycomb family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Acetyltransferase; Nuclear envelope Chromosomal Location of Human Ortholog: 10p11 Cellular Component: NuA4 histone acetyltransferase complex; nuclear membrane; nucleoplasm; nucleus Molecular Function:histone acetyltransferase activity; protein binding Biological Process: negative regulation of gene expression, epigenetic; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012] |
| UniProt Code: | Q9H2F5 |
| NCBI GenInfo Identifier: | 59797889 |
| NCBI Gene ID: | 80314 |
| NCBI Accession: | Q9H2F5.1 |
| UniProt Secondary Accession: | Q9H2F5,Q5VW54, Q5VW56, Q5VW58, Q8NAQ4, Q8NE21, Q96LF4 Q96RR6, Q9H7T7, B4DSC3, D3DRX7, |
| UniProt Related Accession: | Q9H2F5 |
| Molecular Weight: | 85,222 Da |
| NCBI Full Name: | Enhancer of polycomb homolog 1 |
| NCBI Synonym Full Names: | enhancer of polycomb homolog 1 |
| NCBI Official Symbol: | EPC1 |
| NCBI Official Synonym Symbols: | Epl1 |
| NCBI Protein Information: | enhancer of polycomb homolog 1 |
| UniProt Protein Name: | Enhancer of polycomb homolog 1 |
| Protein Family: | Enhancer of polycomb |
| UniProt Gene Name: | EPC1 |
| UniProt Entry Name: | EPC1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using EPC1 antibody (CAB5807) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of U2OS cells using EPC1 antibody (CAB5807). Blue: DAPI for nuclear staining. |
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