Anti-EPB41 Antibody (CAB2490)

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SKU:
CAB2490
Product type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle
Frequently bought together:

Description

system_update_alt데이터시트system_update_alt안전 데이터시트
Antibody Name:Anti-EPB41 Antibody
Antibody SKU:CAB2490
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 210-500 of human EPB41 (NP_001159478.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:293T, Mouse brain, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 210-500 of human EPB41 (NP_001159478.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MHCK VSLL DDTV YECV VEKH AKGQ DLLK RVCE HLNL LEED YFGL AIWD NATS KTWL DSAK EIKK QVRG VPWN FTFN VKFY PPDP AQLT EDIT RYYL CLQL RQDI VAGR LPCS FATL ALLG SYTI QSEL GDYD PELH GVDY VSDF KLAP NQTK ELEE KVME LHKS YRSM TPAQ ADLE FLEN AKKL SMYG VDLH KAKD LEGV DIIL GVCS SGLL VYKD KLRI NRFP WPKV LKIS YKRS SFFI KIRP GEQE QYES TIGF KLPS YRAA KKLW KVCV EHHT FFRL TSTD TIPK SKF
Gene ID:2035
Uniprot:P11171
Cellular Location:Cytoplasm, Nucleus, cell cortex, cytoskeleton
Calculated MW:63kDa/66kDa/71kDa/81kDa/86kDa/93kDa/97kDa
Observed MW:90-97kDa
Synonyms:EPB41, 4.1R, EL1, HE
Background:The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
UniProt Protein Function:Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes.
NCBI Summary:The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009]
UniProt Code:P11171
NCBI GenInfo Identifier:90101808
NCBI Gene ID:2035
NCBI Accession:P11171.4
UniProt Secondary Accession:P11171,P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578 Q9Y579, B1ALH8, B1ALH9, D3DPM9, D3DPN0,
UniProt Related Accession:P11171
Molecular Weight:97kDa
NCBI Full Name:Protein 4.1
NCBI Synonym Full Names:erythrocyte membrane protein band 4.1
NCBI Official Symbol:EPB41  
NCBI Official Synonym Symbols:HE; EL1; 4.1R  
NCBI Protein Information:protein 4.1
UniProt Protein Name:Protein 4.1
UniProt Synonym Protein Names:4.1R; Band 4.1; EPB4.1
Protein Family:Erythroid protein
UniProt Gene Name:EPB41  
Anti-EPB41 Antibody (CAB2490)Western blot analysis of extracts of various cell lines, using EPB41 antibody (CAB2490) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Anti-EPB41 Antibody (CAB2490)Immunohistochemistry of paraffin-embedded human colon carcinoma using EPB41 antibody (CAB2490) at dilution of 1:100 (40x lens).
Anti-EPB41 Antibody (CAB2490)Immunohistochemistry of paraffin-embedded human gastric cancer using EPB41 antibody (CAB2490) at dilution of 1:100 (40x lens).
Anti-EPB41 Antibody (CAB2490)Immunofluorescence analysis of U2OS cells using EPB41 antibody (CAB2490). Blue: DAPI for nuclear staining.

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