Anti-EP400 Antibody (CAB12151)
- SKU:
- CAB12151
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-EP400 Antibody |
| Antibody SKU: | CAB12151 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 90-330 of human EP400 (NP_056224.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Human |
| Positive Samples: | HeLa, Jurkat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 90-330 of human EP400 (NP_056224.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TLAP LPLP SPTS PGFQ FSAQ PRRF EHGS PSYI QVTS PLSQ QVQT QSPT QPSP GPGQ ALQN VRAG APGP GLGL CSSS PTGG FVDA SVLV RQIS LSPS SGGH FVFQ DGSG LTQI AQGA QVQL QHPG TPIT VRER RPSQ PHTQ SGGT IHHL GPQS PAAA GGAG LQPL ASPS HITT ANLP PQIS SIIQ GQLV QQQQ VLQG PPLP RPLG FERT PGVL LPGA GGAA GFGM TSPP PPTS PSRT AVPP G |
| Gene ID: | 57634 |
| Uniprot: | Q96L91 |
| Cellular Location: | Nucleus |
| Calculated MW: | 331kDa/335kDa/339kDa/343kDa |
| Observed MW: | 400kDa |
| Synonyms: | EP400, CAGH32, P400, TNRC12 |
| Background: |
| UniProt Protein Function: | p400: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Apoptosis; EC 3.6.1.-; EC 3.6.4.-; Helicase Chromosomal Location of Human Ortholog: 12q24.33 Cellular Component: NuA4 histone acetyltransferase complex; nuclear speck; nucleoplasm Molecular Function:protein binding |
| UniProt Code: | Q96L91 |
| NCBI GenInfo Identifier: | 317373565 |
| NCBI Gene ID: | 57634 |
| NCBI Accession: | Q96L91.4 |
| UniProt Secondary Accession: | Q96L91,O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230 |
| UniProt Related Accession: | Q96L91 |
| Molecular Weight: | 343kDa |
| NCBI Full Name: | E1A-binding protein p400 |
| NCBI Synonym Full Names: | E1A binding protein p400 |
| NCBI Official Symbol: | EP400 |
| NCBI Official Synonym Symbols: | P400; CAGH32; TNRC12 |
| NCBI Protein Information: | E1A-binding protein p400 |
| UniProt Protein Name: | E1A-binding protein p400 |
| UniProt Synonym Protein Names: | CAG repeat protein 32; Domino homolog; hDomino; Trinucleotide repeat-containing gene 12 protein; p400 kDa SWI2/SNF2-related protein |
| Protein Family: | E1A-binding protein |
| UniProt Gene Name: | EP400 |
 | Western blot analysis of extracts of various cell lines, using EP400 antibody (CAB12151) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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