Anti-ELP2 Antibody (CAB15857)

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SKU:
CAB15857
Product type:
Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
Frequently bought together:

Description

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Antibody Name:Anti-ELP2 Antibody
Antibody SKU:CAB15857
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 300-600 of human ELP2 (NP_001229808.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Mouse heart, Mouse kidney, Rat spleen
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 300-600 of human ELP2 (NP_001229808.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QNTV NPRE WTPE IVIS GHFD GVQD LVWD PEGE FIIT VGTD QTTR LFAP WKRK DQSQ VTWH EIAR PQIH GYDL KCLA MINR FQFV SGAD EKVL RVFS APRN FVEN FCAI TGQS LNHV LCNQ DSDL PEGA TVPA LGLS NKAV FQGD IASQ PSDE EELL TSTG FEYQ QVAF QPSI LTEP PTED HLLQ NTLW PEVQ KLYG HGYE IFCV TCNS SKTL LASA CKAA KKEH AAII LWNT TSWK QVQN LVFH SLTV TQMA FSPN EKFL LAVS RDRT WSLW KKQD TISP EFEP VFSL FAFT NKIT SVHS R
Gene ID:55250
Uniprot:Q6IA86
Cellular Location:Cytoplasm, Nucleus
Calculated MW:78kDa/84kDa/89kDa/92kDa/99kDa
Observed MW:92kDa
Synonyms:ELP2, MRT58, SHINC-2, STATIP1, StIP
Background:The protein encoded by this gene is a core subunit of the elongator complex, a histone acetyltransferase complex that associates with RNA polymerase II. In addition to histone acetylation, the encoded protein effects transcriptional elongation and may help remodel chromatin.
UniProt Protein Function:ELP2: Regulates the ligand-dependent activation of STAT3. Belongs to the WD repeat ELP2 family. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 18q12.2

Cellular Component: cytoplasm; Elongator holoenzyme complex; histone acetyltransferase complex; transcription elongation factor complex; transcriptional repressor complex

Molecular Function:histone binding

Biological Process: regulation of transcription from RNA polymerase II promoter; RNA elongation from RNA polymerase II promoter

NCBI Summary:The protein encoded by this gene is a core subunit of the elongator complex, a histone acetyltransferase complex that associates with RNA polymerase II. In addition to histone acetylation, the encoded protein effects transcriptional elongation and may help remodel chromatin. [provided by RefSeq, May 2016]
UniProt Code:Q6IA86
NCBI GenInfo Identifier:83305834
NCBI Gene ID:55250
NCBI Accession:Q6IA86.2
UniProt Secondary Accession:Q6IA86,Q53GZ0, Q687Y8, Q8N5C2, Q96GV4, Q96PI7, Q9H9N0 A8KAI6, B4DTG0, B4DXP0, E7EP23, E9PCX0,
UniProt Related Accession:Q6IA86
Molecular Weight:84,688 Da
NCBI Full Name:Elongator complex protein 2
NCBI Synonym Full Names:elongator acetyltransferase complex subunit 2
NCBI Official Symbol:ELP2  
NCBI Official Synonym Symbols:StIP; SHINC-2; STATIP1  
NCBI Protein Information:elongator complex protein 2
UniProt Protein Name:Elongator complex protein 2
UniProt Synonym Protein Names:SHINC-2; STAT3-interacting protein 1; StIP1
Protein Family:Elongator complex protein
UniProt Gene Name:ELP2  
UniProt Entry Name:ELP2_HUMAN
Anti-ELP2 Antibody (CAB15857)Western blot analysis of extracts of various cell lines, using ELP2 antibody (CAB15857) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.

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