Anti-ELMO3 Antibody (CAB7182)
- SKU:
- CAB7182
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-ELMO3 Antibody |
| Antibody SKU: | CAB7182 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 504-773 of human ELMO3 (NP_078988.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 22Rv1, SW480, HT-29, Mouse brain, Mouse liver, Mouse kidney, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 504-773 of human ELMO3 (NP_078988.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NKTW KEMR ATQE DFDK VMQV VREQ LART LALK PTSL ELFR TKVN ALTY GEVL RLRQ TERL HQEG TLAP PILE LREK LKPE LMGL IRQQ RLLR LCEG TLFR KISS RRRQ DKLW FCCL SPNH KLLQ YGDM EEGA SPPT LESL PEQL PVAD MRAL LTGK DCPH VREK GSGK QNKD LYEL AFSI SYDR GEEE AYLN FIAP SKRE FYLW TDGL SALL GSPM GSEQ TRLD LEQL LTME TKLR LLEL ENVP IPER PPPV PPPP TNFN FCYD CSIA EP |
| Gene ID: | 79767 |
| Uniprot: | Q96BJ8 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 68kDa/81kDa/87kDa |
| Observed MW: | 81kDa |
| Synonyms: | ELMO3, CED-12, CED12, ELMO-3 |
| Background: | The protein encoded by this gene is similar to a C. elegans protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins have been shown to interact with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes. |
| UniProt Protein Function: | ELMO3: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: cytoskeleton; cytoplasm Molecular Function:SH3 domain binding Biological Process: apoptosis; phagocytosis |
| NCBI Summary: | The protein encoded by this gene is similar to a C. elegans protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins have been shown to interact with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96BJ8 |
| NCBI GenInfo Identifier: | 238054390 |
| NCBI Gene ID: | 79767 |
| NCBI Accession: | Q96BJ8.3 |
| UniProt Secondary Accession: | Q96BJ8,Q9H8A5, B4DV86, |
| UniProt Related Accession: | Q96BJ8 |
| Molecular Weight: | 720 |
| NCBI Full Name: | Engulfment and cell motility protein 3 |
| NCBI Synonym Full Names: | engulfment and cell motility 3 |
| NCBI Official Symbol: | ELMO3 |
| NCBI Official Synonym Symbols: | CED12; CED-12; ELMO-3 |
| NCBI Protein Information: | engulfment and cell motility protein 3; ced-12 homolog 3 |
| UniProt Protein Name: | Engulfment and cell motility protein 3 |
| Protein Family: | Engulfment and cell motility protein |
| UniProt Gene Name: | ELMO3 |
| UniProt Entry Name: | ELMO3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ELMO3 antibody (CAB7182) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human kidney using ELMO3 antibody (CAB7182) at dilution of 1:100 (40x lens). |
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