Anti-ELMO2 Antibody (CAB13785)
- SKU:
- CAB13785
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-ELMO2 Antibody |
| Antibody SKU: | CAB13785 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 42-120 of human ELMO2 (NP_877496.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 42-120 of human ELMO2 (NP_877496.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SLPN PEYY TLRY ADGP QLYI TEQT RSDI KNGT ILQL AISP SRAA RQLM ERTQ SSNM ETRL DAMK ELAK LSAD VTFA TEF |
| Gene ID: | 63916 |
| Uniprot: | Q96JJ3 |
| Cellular Location: | Cytoplasm, Membrane, cytosol |
| Calculated MW: | 72kDa/82kDa |
| Observed MW: | 83kDa |
| Synonyms: | ELMO2, CED-12, CED12, Ced-12A, ELMO-2, VMPI |
| Background: | The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | ELMO2: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 20q13 Cellular Component: cytoplasm; cytosol; membrane Molecular Function:protein binding; receptor tyrosine kinase binding Biological Process: vascular endothelial growth factor receptor signaling pathway |
| NCBI Summary: | The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q96JJ3 |
| NCBI GenInfo Identifier: | 30913107 |
| NCBI Gene ID: | 63916 |
| NCBI Accession: | Q96JJ3.2 |
| UniProt Secondary Accession: | Q96JJ3,Q5JVZ6, Q7Z5G9, Q96CJ2, Q96ME5, Q96PA9, Q9H938 Q9H9L5, Q9HAH0, Q9NQQ6, E1P5T3, |
| UniProt Related Accession: | Q96JJ3 |
| Molecular Weight: | 72,798 Da |
| NCBI Full Name: | Engulfment and cell motility protein 2 |
| NCBI Synonym Full Names: | engulfment and cell motility 2 |
| NCBI Official Symbol: | ELMO2 |
| NCBI Official Synonym Symbols: | CED12; CED-12; ELMO-2; Ced-12A |
| NCBI Protein Information: | engulfment and cell motility protein 2 |
| UniProt Protein Name: | Engulfment and cell motility protein 2 |
| UniProt Synonym Protein Names: | Protein ced-12 homolog A; hCed-12A |
| Protein Family: | Engulfment and cell motility protein |
| UniProt Gene Name: | ELMO2 |
| UniProt Entry Name: | ELMO2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ELMO2 antibody (CAB13785) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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