Anti-ELMO1 Antibody (CAB14830)
- SKU:
- CAB14830
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-ELMO1 Antibody |
| Antibody SKU: | CAB14830 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 527-727 of human ELMO1 (NP_055615.8). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 5637, NCI-H460, BxPC-3, LO2, Mouse eye, Mouse testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 527-727 of human ELMO1 (NP_055615.8). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DFQS RPIL ELKE KIQP EILE LIKQ QRLN RLVE GTCF RKLN ARRR QDKF WYCR LSPN HKVL HYGD LEES PQGE VPHD SLQD KLPV ADIK AVVT GKDC PHMK EKGA LKQN KEVL ELAF SILY DSNC QLNF IAPD KHEY CIWT DGLN ALLG KDMM SDLT RNDL DTLL SMEI KLRL LDLE NIQI PDAP PPIP KEPS NYDF VYDC N |
| Gene ID: | 9844 |
| Uniprot: | Q92556 |
| Cellular Location: | Cell membrane, Cytoplasm |
| Calculated MW: | 28kDa/49kDa/83kDa |
| Observed MW: | 75kDa |
| Synonyms: | ELMO1, CED-12, CED12, ELMO-1 |
| Background: | This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | ELMO1: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 7p14.1 Cellular Component: cytoplasm; cytosol; membrane; plasma membrane Molecular Function:guanyl-nucleotide exchange factor activity; protein binding; SH3 domain binding Biological Process: actin cytoskeleton organization and biogenesis; apoptosis; cell migration; cell motility; phagocytosis, engulfment; positive regulation of GTPase activity; Rac protein signal transduction; regulation of defense response to virus by virus; vascular endothelial growth factor receptor signaling pathway |
| NCBI Summary: | This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q92556 |
| NCBI GenInfo Identifier: | 18765700 |
| NCBI Gene ID: | 9844 |
| NCBI Accession: | NP_055615.8 |
| UniProt Secondary Accession: | Q92556,Q29R79, Q6ZTJ0, Q96PB0, Q9H0I1, A4D1X6, |
| UniProt Related Accession: | Q92556 |
| Molecular Weight: | 49,915 Da |
| NCBI Full Name: | engulfment and cell motility protein 1 isoform 1 |
| NCBI Synonym Full Names: | engulfment and cell motility 1 |
| NCBI Official Symbol: | ELMO1 |
| NCBI Official Synonym Symbols: | CED12; CED-12; ELMO-1 |
| NCBI Protein Information: | engulfment and cell motility protein 1 |
| UniProt Protein Name: | Engulfment and cell motility protein 1 |
| UniProt Synonym Protein Names: | Protein ced-12 homolog |
| Protein Family: | Engulfment and cell motility protein |
| UniProt Gene Name: | ELMO1 |
| UniProt Entry Name: | ELMO1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ELMO1 antibody (CAB14830) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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