Anti-eIF5A Antibody (CAB4414)
- SKU:
- CAB4414
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- EIF-5A
- EIF5A1
- eIF5AI
Description
| Product Name: | eIF5A Rabbit mAb |
| Product Code: | CAB4414 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | EIF-5A, EIF5A1, eIF5AI |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human eIF5A |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Jurkat, HUVEC, Mouse testis, Mouse pancreas, Rat lung, Rat testis, Rat spleen |
| Immunogen: | A synthesized peptide derived from human eIF5A |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1984 |
| Uniprot: | P63241 |
| Cellular Location: | Cytoplasm, Cytoplasmic side, Endoplasmic reticulum membrane, Nucleus, Peripheral membrane protein, nuclear pore complex |
| Calculated MW: | 18kDa |
| Observed MW: | 18KDa |
| UniProt Protein Function: | EIF5A: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF- alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts. Belongs to the eIF-5A family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Translation initiation; Translation Chromosomal Location of Human Ortholog: 17p13-p12 Cellular Component: endoplasmic reticulum membrane; membrane; cytoplasm; nuclear pore; cytosol; nucleus; annulate lamellae Molecular Function:protein binding; RNA binding; ribosome binding; protein N-terminus binding; translation elongation factor activity; U6 snRNA binding Biological Process: mRNA export from nucleus; translational frameshifting; cellular protein metabolic process; apoptosis; positive regulation of cell proliferation; nucleocytoplasmic transport; positive regulation of translational elongation; hypusine biosynthetic process from peptidyl-lysine; protein export from nucleus; post-translational protein modification; positive regulation of translational termination |
| UniProt Code: | P63241 |
| NCBI GenInfo Identifier: | 54037409 |
| NCBI Gene ID: | 1984 |
| NCBI Accession: | P63241.2 |
| UniProt Related Accession: | P63241 |
| Molecular Weight: | ~ 18kDa |
| NCBI Full Name: | Eukaryotic translation initiation factor 5A-1 |
| NCBI Synonym Full Names: | eukaryotic translation initiation factor 5A |
| NCBI Official Symbol: | EIF5A |
| NCBI Official Synonym Symbols: | EIF-5A; EIF5A1; eIF-4D; eIF5AI |
| NCBI Protein Information: | eukaryotic translation initiation factor 5A-1 |
| UniProt Protein Name: | Eukaryotic translation initiation factor 5A-1 |
| UniProt Synonym Protein Names: | Eukaryotic initiation factor 5A isoform 1; eIF-5A; Rev-binding factor; eIF-4D |
| Protein Family: | Translation initiation factor |
| UniProt Gene Name: | EIF5A |
| UniProt Entry Name: | IF5A1_HUMAN |
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